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UniProtKB/Swiss-Prot entry O64967

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH2_GOSHI
Primary accession number O64967
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 61)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms HMG-CoA reductase 2
EC 1.1.1.34
Gene name
Name: HMG2
From
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) [TaxID: 3635] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Malvales; Malvaceae; Malvoideae; Gossypium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Acala SJ2;
Loguercio L.L., Wilkins T.A.;
"Two genomic clones encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase from cotton (Gossypium hirsutum L.).";
(er) Plant Gene Register PGR98-031.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF038046; AAC05089.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09785; T09785.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase O64967.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0042170; Cellular component: plastid membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O64967.
Other
ProtoNet O64967.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; Mitochondrion; NADP; Oxidoreductase; Plastid; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   628  628     3-hydroxy-3-methylglutaryl-coenzyme A reductase 2. PRO_0000114439
TRANSMEM   38    58  21     Potential. 
TRANSMEM   78    98  21     Potential. 
REGION   99   212  114     Linker (By similarity). 
REGION   213   628  416     Catalytic (By similarity). 
ACT_SITE   307   307        Charge relay system (By similarity). 
ACT_SITE   439   439        Charge relay system (By similarity). 
ACT_SITE   515   515        Charge relay system (By similarity). 
ACT_SITE   613   613        Proton donor (By similarity). 
CARBOHYD   153   153        N-linked (GlcNAc...) (Potential). 
CARBOHYD   371   371        N-linked (GlcNAc...) (Potential). 
CARBOHYD   484   484        N-linked (GlcNAc...) (Potential). 
CARBOHYD   617   617        N-linked (GlcNAc...) (Potential). 
CARBOHYD   625   625        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 628 AA [This is the length of the unprocessed precursor] Molecular weight: 67603 Da [This is the MW of the unprocessed precursor] CRC64: BF7704C30EA334F5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEASRRSAVK PVIVLKPSKR FPLVEDTPGK ASDALPLPLY LTNAVFFTLF FTVVYFLLSR 

        70         80         90        100        110        120 
WREKIRASIP LHAVTFPEIV AIFAFVASLI YLLGFFGIDF VQSLIIRPSG DVWSGEDYEE 

       130        140        150        160        170        180 
ENEVLLHEED ARTVPCGQAL DCSVPSLPHM ARNVTAQRLF DEKPVRVATE EDARKVSCGQ 

       190        200        210        220        230        240 
AVDCSLHSLP PRPPIVTSQK LFHEKTVIVT TEEDEEIIKS VVAGTLPSYS LESKLGDCKR 

       250        260        270        280        290        300 
AAAIRREALQ RLTGRSLSGL PLDGFDYESI LGQCCEMPVG YVQIPVGIAG PLLLNGREYS 

       310        320        330        340        350        360 
VPMATTEGCL VASTNRGCKA IHLSGGATSI LLKDGMTRAP VVRFSTAKRA AELKFYLEDP 

       370        380        390        400        410        420 
ENFDTLAVVF NRSSRFGRLQ SIKCAIAGKN LYLRFTCSTG DAMGMNMVSK GVQNVLDFLQ 

       430        440        450        460        470        480 
TDFPDMDVIG ISGNFCSDKK PAAVNWIEGR GKSVVCEAII EGDVVRKVLK TSVESLVELN 

       490        500        510        520        530        540 
MLKNLTGSAM AGALGGFNAH ASNIVTAIYI ATGQDPAQNV ESSHCITMME AVNDGKDLHI 

       550        560        570        580        590        600 
SVTMPSIEVG TVGGGTQLAS QSACLNLLGV KGASKDVAGA NSRMLATIVT GAVLAGELSL 

       610        620 
MSALAAGQLV KSHMKYNRSS KDMSNLSS
O64967 in FASTA format

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