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UniProtKB/Swiss-Prot entry O66976

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_AQUAE
Primary accession number O66976
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: aq_782
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC06931.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E70368; E70368.
RefSeq NP_213537.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase O66976.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_782-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS O66976.
Genome annotation databases
GeneID 1193426; -.
GenomeReviews AE000657_GR; aq_782.
KEGG aae:aq_782; -.
NMPDR fig|224324.1.peg.552; -.
Phylogenomic databases
HOGENOM O66976; -.
Genome annotation databases
CMR O66976; aq_782.
Other
ProtoNet O66976.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   426  426     Histidinol dehydrogenase. PRO_0000135717
ACT_SITE   323   323        Proton acceptor (By similarity). 
ACT_SITE   324   324        Proton acceptor (By similarity). 
METAL   255   255        Zinc (By similarity). 
METAL   258   258        Zinc (By similarity). 
METAL   357   357        Zinc (By similarity). 
METAL   416   416        Zinc (By similarity). 
BINDING   130   130        NAD (By similarity). 
BINDING   187   187        NAD (By similarity). 
BINDING   210   210        NAD (By similarity). 
BINDING   233   233        Substrate (By similarity). 
BINDING   255   255        Substrate (By similarity). 
BINDING   258   258        Substrate (By similarity). 
BINDING   324   324        Substrate (By similarity). 
BINDING   357   357        Substrate (By similarity). 
BINDING   411   411        Substrate (By similarity). 
BINDING   416   416        Substrate (By similarity). 
Sequence information
Length: 426 AA [This is the length of the unprocessed precursor] Molecular weight: 47447 Da [This is the MW of the unprocessed precursor] CRC64: 3F54ED61A772C005 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRIEDLRKED WKLNERLEYL AKRGEILEEE YEKSVKEILK RVREEGDRAV IEFTKKFDGV 

        70         80         90        100        110        120 
ELTPENMEVP FEELEKAYEE IEPEVREALE FAENRIRVFH EKQLENSFFK EEEGIILGQK 

       130        140        150        160        170        180 
VVPLEKVGVY VPGGKAAYPS TVLMNVVPAS VAGVEEIIMV SPKPNKYTLA AAYIAGVSRV 

       190        200        210        220        230        240 
FQVGGAQAIG ALAYGTEKIP KVDKIVGPGN IYVALAKKLV FGTVDIDMIA GPSEVLVIAD 

       250        260        270        280        290        300 
ERANPTWVAA DMLSQAEHDE LAASILLTPS EELANKVKEE VERLLSQLER KEIAQKSLEK 

       310        320        330        340        350        360 
FGTIFLVKDL YHACEVANYI APEHLEVMVR EPMALLPELK HAGAIFLGDY TTEPLGDYVL 

       370        380        390        400        410        420 
GPNHTLPTGG STRFFSPLGV YDFIKRSSVL YVSREGFKRV ANQAEAIAKA EGLTAHALAV 


KVRKND
O66976 in FASTA format

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