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UniProtKB/Swiss-Prot entry O67422


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name METF_AQUAE
Primary accession number O67422
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 46)
Name and origin of the protein
Protein name 5,10-methylenetetrahydrofolate reductase
Synonym EC 1.5.1.20
Gene name
Name: metF
OrderedLocusNames: aq_1429
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC07387.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D70424; D70424.
RefSeq NP_213987.1; -.
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
ModBase O67422.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_1429-MON; -.
Family and domain databases
InterPro IPR003171; Mehydrof_redctse.
IPR004620; MTHF_reductase_bac.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00676; fadh2; 1.
BLOCKS O67422.
Genome annotation databases
GeneID 1192953; -.
GenomeReviews AE000657_GR; aq_1429.
KEGG aae:aq_1429; -.
NMPDR fig|224324.1.peg.1002; -.
Phylogenomic databases
HOGENOM O67422; -.
Genome annotation databases
CMR O67422; aq_1429.
Other
ProtoNet O67422.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein; Methionine biosynthesis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   296  296     5,10-methylenetetrahydrofolate reductase. PRO_0000190257
Sequence information
Length: 296 AA [This is the length of the unprocessed precursor] Molecular weight: 33871 Da [This is the MW of the unprocessed precursor] CRC64: E497CC6CAC9FAFC0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKIGDILRKG VFSISFEFFP PKTEEGERQL FETIRKLEKL NPTFVSVTYG AGGSTRDRTR 

        70         80         90        100        110        120 
NIVQKIHEET NLTVMAHLTC IAHTREELID ILQDYKNIGI ENILALRGDV PRDKPDWRPP 

       130        140        150        160        170        180 
KGACKYAKEL VELIRKEFGD WFSIGVASYP EGHPESPNLE WEVKYFKEKV EAGADFSITQ 

       190        200        210        220        230        240 
MFFVNDYYYR FVEMCKNAGI DISIIPGIMP ITNFKQIRKF ASLCGATIPQ SLIEKLEKVE 

       250        260        270        280        290 
DKPEEVKKIG IEFAINQCLD LIEHGVPGLH FYTLNKSDAT LKIYEAIKDK IPARST 

O67422 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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