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UniProtKB/Swiss-Prot entry O80585


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTHR2_ARATH
Primary accession number O80585
Secondary accession numbers Q56ZL2 Q94JZ1 Q9SE59 Q9SUJ0
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on August 2, 2002 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 62)
Name and origin of the protein
Protein name Methylenetetrahydrofolate reductase 2
Synonyms AtMTHFR2
EC 1.5.1.20
Gene name
Name: MTHFR2
OrderedLocusNames: At2g44160
ORFNames: F6E13.29
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Ravanel S., Rebeille F., Douce R.;
"Folate metabolism in higher plants: cloning of a cDNA for 5,10-methylenetetrahydrofolate reductase in Arabidopsis thaliana.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND ENZYME REGULATION.
DOI=10.1074/jbc.274.51.36089; PubMed=10593891 [NCBI, ExPASy, EBI, Israel, Japan]
Roje S., Wang H., McNeil S.D., Raymond R.K., Appling D.R., Shachar-Hill Y., Bohnert H.J., Hanson A.D.;
"Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants.";
J. Biol. Chem. 274:36089-36096(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-594.
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K., Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ245414; CAB53783.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF181967; AAD55788.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004005; AAC23420.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY050434; AAK91450.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF370515; AAK43892.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK220952; BAD94483.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T00696; T00696.
RefSeq NP_566011.1; -.
UniGene At.23509
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
ModBase O80585.
Organism-specific databases
GeneFarm 5158; 490.
TAIR At2g44160; -.
Gene expression databases
ArrayExpress O80585; -.
GermOnline AT2G44160; Arabidopsis thaliana.
Family and domain databases
InterPro IPR004621; Fadh2_euk.
IPR003171; Mehydrof_redctse.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00677; fadh2_euk; 1.
BLOCKS O80585.
Proteomic databases
ProMEX O80585; -.
Genome annotation databases
GeneID 819022; -.
GenomeReviews CT485783_GR; AT2G44160.
KEGG ath:AT2G44160; -.
NMPDR fig|3702.1.peg.11589; -.
Other
ProtoNet O80585.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   594  594     Methylenetetrahydrofolate reductase 2. PRO_0000190250
CONFLICT   72    72        N -> S (in Ref. 1; CAB53783). 
CONFLICT   115   115        P -> H (in Ref. 4; AAK43892). 
CONFLICT   508   508        A -> V (in Ref. 1; CAB53783). 
Sequence information
Length: 594 AA [This is the length of the unprocessed precursor] Molecular weight: 66802 Da [This is the MW of the unprocessed precursor] CRC64: E2F4F919FCE10EF8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKVIDKIQSL ADEGKTAFSF EFFPPKTEDG VDNLFERMDR MVAYGPTFCD ITWGAGGSTA 

        70         80         90        100        110        120 
DLTLDIASRM QNVVCVESMM HLTCTNMPVE KIDHALETIR SNGIQNVLAL RGDPPHGQDK 

       130        140        150        160        170        180 
FVQVEGGFDC ALDLVNHIRS KYGDYFGITV AGYPEAHPDV IGENGLASNE AYQSDLEYLK 

       190        200        210        220        230        240 
KKIDAGADLI VTQLFYDTDI FLKFVNDCRQ IGISCPIVPG IMPINNYRGF LRMTGFCKTK 

       250        260        270        280        290        300 
IPVEVMAALE PIKDNEEAVK AYGIHLGTEM CKKMLAHGVK SLHLYTLNME KSALAILMNL 

       310        320        330        340        350        360 
GMIDESKISR SLPWRRPANV FRTKEDVRPI FWANRPKSYI SRTKGWEDFP QGRWGDSRSA 

       370        380        390        400        410        420 
SYGALSDHQF SRPRARDKKL QQEWVVPLKS VEDIQEKFKE LCLGNLKSSP WSELDGLQPE 

       430        440        450        460        470        480 
TRIINEQLIK VNSKGFLTIN SQPSVNAERS DSPTVGWGGP VGYVYQKAYL EFFCSKEKLD 

       490        500        510        520        530        540 
AVVEKCKALP SITYMAVNKG EQWVSNTAQA DVNAVTWGVF PAKEIIQPTI VDPASFNVWK 

       550        560        570        580        590 
DEAFETWSRS WANLYPEADP SRNLLEEVKN SYYLVSLVEN DYINGDIFAV FADL 

O80585 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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