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UniProtKB/Swiss-Prot entry O84375

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARODE_CHLTR
Primary accession number O84375
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Shikimate biosynthesis protein aroDE
Synonyms None
Includes 3-dehydroquinate dehydratase
     (3-dehydroquinase)
     (EC 4.2.1.10)
     (Type I DHQase)
Shikimate dehydrogenase
     (EC 1.1.1.25)
Gene name
Name: aroE
Synonyms: aroD/E
OrderedLocusNames: CT_370
From
Chlamydia trachomatis [TaxID: 813] [HAMAP proteome]
Taxonomy Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=D/UW-3/Cx;
DOI=10.1126/science.282.5389.754; PubMed=9784136 [NCBI, ExPASy, EBI, Israel, Japan]
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.";
Science 282:754-759(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001273; AAC67966.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C71523; C71523.
RefSeq NP_219879.1; -.
3D structure databases
ModBase O84375.
Enzyme and pathway databases
BioCyc CTRA315277:CT370-MON; -.
Ontologies
GO
GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity (inferred from electronic annotation from HAMAP).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00214; fused; 1.
MF_00222; fused; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR001381; DHquinase_I.
IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01487; DHquinase_I; 1.
PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
ProDom PD005337; DHquinase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00507; aroE; 1.
PROSITE PS01028; DEHYDROQUINASE_I; FALSE_NEG.
BLOCKS O84375.
Genome annotation databases
GeneID 884748; -.
GenomeReviews AE001273_GR; CT_370.
KEGG ctr:CT370; -.
Phylogenomic databases
HOGENOM O84375; -.
Genome annotation databases
CMR O84375; CT_370.
Other
ProtoNet O84375.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Multifunctional enzyme; NADP; Oxidoreductase; Schiff base.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   478  478     Shikimate biosynthesis protein aroDE. PRO_0000138824
NP_BIND   337   341  5     NADP (By similarity). 
REGION   1   208  208     3-dehydroquinate dehydratase. 
REGION   209   478  270     Shikimate 5-dehydrogenase. 
COMPBIAS   137   140  4     Poly-Ser. 
ACT_SITE   110   110        Proton acceptor (By similarity). 
ACT_SITE   133   133        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 478 AA [This is the length of the unprocessed precursor] Molecular weight: 53098 Da [This is the MW of the unprocessed precursor] CRC64: 200DB65E1B081D53 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLCTTISGPS FLEAKKQILR SLKECHCFEM RVDLLSVSCL ELKKLMELAP ISILAWKKPE 

        70         80         90        100        110        120 
SCSQADWIDK MQSLAELNPN YLDLEKDFPE EDMIRIRQLH PQIKIIRSLH TSEHTDIIQL 

       130        140        150        160        170        180 
YAHMRSSAAD YYKFAVSSSS TTDLLDICHQ KRSLPENTTV VCLGGMGRPS RILSPILQNP 

       190        200        210        220        230        240 
FTYARSTGSS PVAPGQFSLK HHYFYNFASL SAQSPICALI GDTSRSIGHL THNPFFSQLG 

       250        260        270        280        290        300 
VACPYIKLPL TPQELPKFFS TIRTQPFLGV SVTSPLKTAV LPFLDKQAPS VKASGSCNTL 

       310        320        330        340        350        360 
VIRQGEIEGH DTDGEGLFSV LMQHQIPLNN QRVAIIGAGG AAQSIATRLS RANCELLIFN 

       370        380        390        400        410        420 
RTKAHAEDLA SRCQAKAFSL EELPLHRVSL IINCLPPSCT IPKAVAPCVV DINTIPKHST 

       430        440        450        460        470 
FTQYARSQGS SIIYGHEMFT QQALLQFRLW FPTLSFKHLE KTFIRRAAVL ASLFSIAP
O84375 in FASTA format

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