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UniProtKB/Swiss-Prot entry O93344

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1A2_CHICK
Primary accession number O93344
Secondary accession number Q549A6
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 53)
Name and origin of the protein
Protein name Retinal dehydrogenase 2
Synonyms RALDH 2
RalDH2
EC 1.2.1.36
Aldehyde dehydrogenase family 1 member A2
Retinaldehyde-specific dehydrogenase type 2
RALDH(II)
Gene name
Name: ALDH1A2
Synonyms: RALDH2
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0092-8674(00)81591-3; PubMed=9727493 [NCBI, ExPASy, EBI, Israel, Japan]
Sockanathan S., Jessell T.M.;
"Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons.";
Cell 94:503-514(1998).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 20-518.
Capdevila J.;
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF064253; AAC34299.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF181680; AAF00485.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_990326.1; -.
UniGene Gga.2996
3D structure databases
HSSP Q63639; 1BI9. [HSSP ENTRY / PDB]
ModBase O93344.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS O93344.
Genome annotation databases
Ensembl ENSGALG00000004270; Gallus gallus. [Contig view]
GeneID 395844; -.
KEGG gga:395844; -.
Phylogenomic databases
HOGENOM O93344; -.
HOVERGEN O93344; -.
Other
ProtoNet O93344.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   518  518     Retinal dehydrogenase 2. PRO_0000056425
NP_BIND   263   268  6     NAD (By similarity). 
ACT_SITE   286   286        Proton acceptor (By similarity). 
ACT_SITE   320   320        Nucleophile (By similarity). 
SITE   187   187  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 518 AA [This is the length of the unprocessed precursor] Molecular weight: 56732 Da [This is the MW of the unprocessed precursor] CRC64: B79FBA3124592460 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTSSKIEMPG EVKADPAALM ASLHLLPSPT LNLEIKHTKI FINNEWQNSE SGRVFPVYNP 

        70         80         90        100        110        120 
ATGEQICEIQ EADKVDTDKA VRAARLAFSL GSVWRRMDAS ERGQLLDKLA DLVERDRAVL 

       130        140        150        160        170        180 
ATMESLNSGK PFLQAFYVDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 

       190        200        210        220        230        240 
GQIIPWNFPL LMFAWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 

       250        260        270        280        290        300 
GFGPIVGAAI ASHVGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 

       310        320        330        340        350        360 
LDYAVEQAHQ GVFFNQGQCC TAGSRIYVEE SIYEEFVRRS VERAKRRVVG SPFDPTTEQG 

       370        380        390        400        410        420 
PQIDKKQYNK ILELIQSGIT EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 

       430        440        450        460        470        480 
PVQEILRFKT VDEVIERANN SDFGLVAAVF TNDINKALTV SSAMQAGTVW INCYNALNAQ 

       490        500        510 
SPFGGFKMSG NGREMGESGL REYSEVKTVT IKIPQKNS
O93344 in FASTA format

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