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UniProtKB/Swiss-Prot entry O93364

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name OXLA_CROAD
Primary accession number O93364
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 54)
Name and origin of the protein
Protein name L-amino-acid oxidase [Precursor]
Synonyms LAAO
LAO
EC 1.4.3.2
Apoxin-1
Apoxin I
Gene name None
From
Crotalus adamanteus (Eastern diamondback rattlesnake) [TaxID: 8729] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 19-44 AND 106-130.
TISSUE=Venom, and Venom gland;
DOI=10.1006/bbrc.1998.9024; PubMed=9703950 [NCBI, ExPASy, EBI, Israel, Japan]
Raibekas A.A., Massey V.;
"Primary structure of the snake venom L-amino acid oxidase shows high homology with the mouse B cell interleukin 4-induced Fig1 protein.";
Biochem. Biophys. Res. Commun. 248:476-478(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF071564; AAC32267.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JE0266; JE0266.
3D structure databases
HSSP P81382; 1F8R. [HSSP ENTRY / PDB]
SMR O93364; 22-504.
ModBase O93364.
Family and domain databases
InterPro IPR000759; Adrndx_reductase.
IPR002937; Amino_oxidase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Pfam PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.
PRINTS PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS O93364.
Phylogenomic databases
HOVERGEN O93364; -.
Other
ProtoNet O93364.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein; Oxidoreductase; Secreted; Signal; Toxin.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   516  498     L-amino-acid oxidase. PRO_0000001706
NP_BIND   105   106  2     FAD (By similarity). 
NP_BIND   484   487  4     FAD (By similarity). 
BINDING   81    81        FAD (By similarity). 
BINDING   89    89        FAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   239   239        Substrate (By similarity). 
BINDING   279   279        FAD; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   390   390        Substrate (By similarity). 
BINDING   475   475        FAD (By similarity). 
CARBOHYD   379   379        N-linked (GlcNAc...) (Potential). 
DISULFID   28   189        By similarity. 
DISULFID   349   430        By similarity. 
Sequence information
Length: 516 AA [This is the length of the unprocessed precursor] Molecular weight: 58662 Da [This is the MW of the unprocessed precursor] CRC64: FDFAA77A49FDA05A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNVFFMFSLL FLAALGSCAH DRNPLEECFR ETDYEEFLEI AKNGLTATSN PKRVVIVGAG 

        70         80         90        100        110        120 
MAGLSAAYVL AGAGHQVTVL EASERVGGRV RTYRKKDWYA NLGPMRLPTK HRIVREYIKK 

       130        140        150        160        170        180 
FDLKLNEFSQ ENENAWYFIK NIRKRVREVK NNPGLLEYPV KPSEEGKSAA QLYVESLRKV 

       190        200        210        220        230        240 
VEELRSTNCK YILDKYDTYS TKEYLLKEGN LSPGAVDMIG DLLNEDSGYY VSFIESLKHD 

       250        260        270        280        290        300 
DIFGYEKRFD EIVGGMDQLP TSMYEAIKEK VQVHFNARVI EIQQNDREAT VTYQTSANEM 

       310        320        330        340        350        360 
SSVTADYVIV CTTSRAARRI KFEPPLPPKK AHALRSVHYR SGTKIFLTCT KKFWEDDGIH 

       370        380        390        400        410        420 
GGKSTTDLPS RFIYYPNHNF TSGVGVIIAY GIGDDANFFQ ALDFKDCADI VINDLSLIHE 

       430        440        450        460        470        480 
LPKEDIQTFC HPSMIQRWSL DKYAMGGITT FTPYQFQHFS EALTAPFKRI YFAGEYTAQF 

       490        500        510 
HGWIDSTIKS GLTAARDVNR ASENPSGIHL SNDNEF
O93364 in FASTA format

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