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UniProtKB/Swiss-Prot entry O95841


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ANGL1_HUMAN
Primary accession number O95841
Secondary accession number Q5T5Z5
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 54)
Name and origin of the protein
Protein name Angiopoietin-related protein 1 [Precursor]
Synonyms Angiopoietin-like 1
Angiopoietin-3
ANG-3
Gene name
Name: ANGPTL1
Synonyms: ANG3, ANGPT3, ARP1
ORFNames: PSEC0154, UNQ162/PRO188
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Heart;
DOI=10.1016/S0014-5793(99)00008-3; PubMed=10025962 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I., Kwak H.J., Ahn J.E., So J.-N., Liu M., Koh K.N., Koh G.Y.;
"Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3.";
FEBS Lett. 443:353-356(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
Ota T., Nishikawa T., Kawai Y., Suzuki Y., Ishii S., Saito K., Yamamoto J., Sugano S., Isogai T.;
"HRI human cDNA sequencing project.";
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF107253; AAD19608.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB056476; BAB40691.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358278; AAQ88645.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355520; CAC13169.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355520; CAI21921.1; ALT_TERM; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC050640; AAH50640.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_004664.1; -.
UniGene Hs.591474
3D structure databases
HSSP P02671; 1FZD. [HSSP ENTRY / PDB]
ModBase O95841.
Organism-specific databases
H-InvDB HIX0023519; -.
HGNC HGNC:489; ANGPTL1.
GenAtlas ANGPTL1.
HPA HPA009976; -.
MIM 603874; gene. [NCBI / EBI]
PharmGKB PA24794; -.
GeneCards O95841.
Gene expression databases
ArrayExpress O95841; -.
CleanEx HS_ANGPTL1; -.
GermOnline ENSG00000116194; Homo sapiens.
Ontologies
GO
GO:0005102; Molecular function: receptor binding (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002181; Fibrinogen_a/b/g_C.
IPR014716; Fibrinogen_a/b/g_C_1.
Graphical view of domain structure.
Gene3D G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
Pfam PF00147; Fibrinogen_C; 1.
Pfam graphical view of domain structure.
SMART SM00186; FBG; 1.
SMART graphical view of domain structure.
PROSITE PS00514; FIBRIN_AG_C_DOMAIN; 1.
BLOCKS O95841.
Genome annotation databases
Ensembl ENSG00000116194; Homo sapiens. [Contig view]
GeneID 9068; -.
KEGG hsa:9068; -.
Phylogenomic databases
HOGENOM O95841; -.
HOVERGEN O95841; -.
Other
SOURCE ANGPTL1; Homo sapiens.
ProtoNet O95841.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Glycoprotein; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    23  23     Potential. 
CHAIN   24   491  468     Angiopoietin-related protein 1. PRO_0000009118
DOMAIN   276   490  215     Fibrinogen C-terminal. 
COILED   80   168  89     Potential. 
CARBOHYD   160   160        N-linked (GlcNAc...) (Potential). 
CARBOHYD   188   188        N-linked (GlcNAc...) (Potential). 
DISULFID   280   309        By similarity. 
DISULFID   432   445        By similarity. 
Sequence information
Length: 491 AA [This is the length of the unprocessed precursor] Molecular weight: 56720 Da [This is the MW of the unprocessed precursor] CRC64: 3C4DB8DEF6CF7E99 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI 

        70         80         90        100        110        120 
TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR 

       130        140        150        160        170        180 
KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA 

       190        200        210        220        230        240 
SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ 

       250        260        270        280        290        300 
RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN 

       310        320        330        340        350        360 
SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS 

       370        380        390        400        410        420 
NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT 

       430        440        450        460        470        480 
LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL 

       490 
RAVQMMIKPI D 

O95841 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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