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UniProtKB/Swiss-Prot entry P00350


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 6PGD_ECOLI
Primary accession number P00350
Secondary accession numbers P78080 Q47571 Q59366 Q59402 Q59411 Q59412 Q59413 Q59414 Q59416 Q79DT3
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 79)
Name and origin of the protein
Protein name 6-phosphogluconate dehydrogenase, decarboxylating
Synonym EC 1.1.1.44
Gene name
Name: gnd
OrderedLocusNames: b2029, JW2011
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(84)90070-2; PubMed=6329905 [NCBI, ExPASy, EBI, Israel, Japan]
Nasoff M.S., Baker H.V. II, Wolf R.E. Jr.;
"DNA sequence of the Escherichia coli gene, gnd, for 6-phosphogluconate dehydrogenase.";
Gene 27:253-264(1984).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ECOR 10;
PubMed=2050640 [NCBI, ExPASy, EBI, Israel, Japan]
Bisercic M., Feutrier J.Y., Reeves P.R.;
"Nucleotide sequences of the gnd genes from nine natural isolates of Escherichia coli: evidence of intragenic recombination as a contributing factor in the evolution of the polymorphic gnd locus.";
J. Bacteriol. 173:3894-3900(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ECOR 45, ECOR 65, ECOR 67, ECOR 68, ECOR 69, and ECOR 70;
PubMed=1938920 [NCBI, ExPASy, EBI, Israel, Japan]
Dykhuizen D.E., Green L.;
"Recombination in Escherichia coli and the definition of biological species.";
J. Bacteriol. 173:7257-7268(1991).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/dnares/3.6.379; PubMed=9097040 [NCBI, ExPASy, EBI, Israel, Japan]
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.;
"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.";
DNA Res. 3:379-392(1996).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
PubMed=2464736 [NCBI, ExPASy, EBI, Israel, Japan]
Miller R.D., Dykhuizen D.E., Hartl D.L.;
"Fitness effects of a deletion mutation increasing transcription of the 6-phosphogluconate dehydrogenase gene in Escherichia coli.";
Mol. Biol. Evol. 5:691-703(1988).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
PubMed=3275621 [NCBI, ExPASy, EBI, Israel, Japan]
Barcak G.J., Wolf R.E. Jr.;
"Comparative nucleotide sequence analysis of growth-rate-regulated gnd alleles from natural isolates of Escherichia coli and from Salmonella typhimurium LT-2.";
J. Bacteriol. 170:372-379(1988).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
STRAIN=O7:K1 / VW187;
PubMed=7677991 [NCBI, ExPASy, EBI, Israel, Japan]
Marolda C.L., Valvano M.A.;
"Identification, expression, and DNA sequence of the GDP-mannose biosynthesis genes encoded by the O7 rfb gene cluster of strain VW187 (Escherichia coli O7:K1).";
J. Bacteriol. 175:148-158(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K02072; AAA23918.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63821; AAA24488.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64326; AAA24204.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64327; AAA24205.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64328; AAA24206.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64329; AAA24207.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64330; AAA24208.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M64331; AAA24209.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC75090.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAA15869.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23181; AAA23924.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18956; AAA23919.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18957; AAA23920.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18960; AAA23922.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF125322; AAC27540.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D64968; DEECGC.
I62463; I62463.
I62465; I62465.
RefSeq AP_002630.1; -.
NP_416533.1; -.
3D structure databases
HSSP P00349; 2PGD. [HSSP ENTRY / PDB]
ModBase P00350.
Protein-protein interaction databases
IntAct P00350; -.
Enzyme and pathway databases
BioCyc EcoCyc:6PGLUCONDEHYDROG-MON; -.
2D gel databases
ECO2DBASE C042.6; 6TH EDITION.
Organism-specific databases
EchoBASE EB0406; -.
EcoGene EG10411; gnd.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR00873; gnd; 1.
PROSITE PS00461; 6PGD; 1.
BLOCKS P00350.
Genome annotation databases
GeneID 946554; -.
GenomeReviews U00096_GR; b2029.
AP009048_GR; JW2011.
KEGG ecj:JW2011; -.
eco:b2029; -.
CMR P00350; b2029.
Other
ProtoNet P00350.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   468  468     6-phosphogluconate dehydrogenase, decarboxylating. PRO_0000090037
VARIANT   2     2  1     S -> L (in strain: ECOR 70). 
VARIANT   32    32  1     F -> Y (in strain: ECOR 70). 
VARIANT   39    39  1     T -> Q (in strain: O7:K1 / VW187). 
VARIANT   52    52  1     V -> D (in strain: ECOR 10). 
VARIANT   55    55  1     Y -> F (in strain: ECOR 10). 
VARIANT   102   102  1     N -> K (in strain: ECOR 65). 
VARIANT   117   117  1     A -> S (in strain: ECOR 70). 
VARIANT   123   125  3     IGT -> YRY (in strain: O7:K1 / VW187). 
VARIANT   170   170  1     V -> F (in strain: ECOR 10). 
VARIANT   175   175  1     A -> S (in strain: ECOR 45). 
VARIANT   209   209  1     N -> S (in strain: ECOR 68). 
VARIANT   211   211  1     T -> S (in strain: ECOR 10 and ECOR 69). 
VARIANT   216   216  1     A -> T (in strain: ECOR 67). 
VARIANT   294   294  1     D -> E (in strain: ECOR 70). 
VARIANT   308   308  1     A -> G (in strain: ECOR 68). 
VARIANT   313   313  1     D -> N (in strain: ECOR 67). 
VARIANT   315   315  1     A -> G (in strain: ECOR 70). 
VARIANT   325   325  1     L -> Q (in strain: ECOR 69). 
VARIANT   330   330  1     I -> S (in strain: ECOR 10). 
VARIANT   350   350  1     D -> A (in strain: ECOR 10 and ECOR 69). 
VARIANT   369   369  1     Q -> R (in strain: ECOR 10). 
VARIANT   422   422  1     S -> A (in strain: ECOR 10, ECOR 65, ECOR 68, ECOR 69 and ECOR 70). 
CONFLICT   306   306        P -> R (in Ref. 1; AAA23918). 
Sequence information
Length: 468 AA [This is the length of the unprocessed precursor] Molecular weight: 51481 Da [This is the MW of the unprocessed precursor] CRC64: 62A32C84DC596D86 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSKQQIGVVG MAVMGRNLAL NIESRGYTVS IFNRSREKTE EVIAENPGKK LVPYYTVKEF 

        70         80         90        100        110        120 
VESLETPRRI LLMVKAGAGT DAAIDSLKPY LDKGDIIIDG GNTFFQDTIR RNRELSAEGF 

       130        140        150        160        170        180 
NFIGTGVSGG EEGALKGPSI MPGGQKEAYE LVAPILTKIA AVAEDGEPCV TYIGADGAGH 

       190        200        210        220        230        240 
YVKMVHNGIE YGDMQLIAEA YSLLKGGLNL TNEELAQTFT EWNNGELSSY LIDITKDIFT 

       250        260        270        280        290        300 
KKDEDGNYLV DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKDQRVAAS 

       310        320        330        340        350        360 
KVLSGPQAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASEEYNWD LNYGEIAKIF 

       370        380        390        400        410        420 
RAGCIIRAQF LQKITDAYAE NPQIANLLLA PYFKQIADDY QQALRDVVAY AVQNGIPVPT 

       430        440        450        460 
FSAAVAYYDS YRAAVLPANL IQAQRDYFGA HTYKRIDKEG VFHTEWLD 

P00350 in FASTA format

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