[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1093/nar/13.9.3063; PubMed=2582370 [NCBI, ExPASy, EBI, Israel, Japan] Ledeboer A.M., Edens L., Maat J., Visser C., Bos J.W., Verrips C.T.; "Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha."; Nucleic Acids Res. 13:3063-3082(1985).
[2]	SIMILARITY TO DROSOPHILA GLUCOSE DEHYDROGENASE. PubMed=2002763 [NCBI, ExPASy, EBI, Israel, Japan] Cavener D.R., Krasney P.; "Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes."; Mol. Biol. Evol. 8:144-150(1991).
[3]	REVIEW. PubMed=1882546 [NCBI, ExPASy, EBI, Israel, Japan] van der Klei I.J., Harder W., Veenhuis M.; "Biosynthesis and assembly of alcohol oxidase, a peroxisomal matrix protein in methylotrophic yeasts: a review."; Yeast 7:195-209(1991).

Comments

CATALYTIC ACTIVITY: A primary alcohol + O₂ = an aldehyde + H₂O₂.
COFACTOR: FAD.
PATHWAY: Energy metabolism; methane degradation .
SUBUNIT: Homooctamer.
SUBCELLULAR LOCATION: Peroxisome.
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X02425; CAA26278.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A23010; OXHQAP.

3D structure databases

ModBase

P04841.

Family and domain databases

InterPro

IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Methanol utilization; Oxidoreductase; Peroxisome.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 664`	`664`	`Alcohol oxidase.`	`PRO_0000205581`
`NP_BIND`	`8 39`	`32`	`FAD (Probable).`
`MOTIF`	`662 664`	`3`	`Microbody targeting signal (Potential).`
`ACT_SITE`	`568 568`		`By similarity.`

Sequence information

Length: 664 AA [This is the length of the unprocessed precursor]

Molecular weight: 74089 Da [This is the MW of the unprocessed precursor]

CRC64: 6A4E3AFD6688BD5D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAIPDEFDII VVGGGSTGCC IAGRLANLDD QNLTVALIEG GENNINNPWV YLPGVYPRNM 

        70         80         90        100        110        120 
RLDSKTATFY SSRPSKALNG RRAIVPCANI LGGGSSINFL MYTRASASDY DDWESEGWST 

       130        140        150        160        170        180 
DELLPLIKKI ETYQRPCNNR DLHGFDGPIK VSFGNYTYPT CQDFLRAAES QGIPVVDDLE 

       190        200        210        220        230        240 
DFKTSHGAEH WLKWINRDLG RRSDSAHAYV HPTMRNKQSL FLITSTKCDK VIIEDGKAVA 

       250        260        270        280        290        300 
VRTVPMKPLN PKKPVSRTFR ARKQIVISCG TISSPLVLQR SGIGAAHHLR SVGVKPIVDL 

       310        320        330        340        350        360 
PGVGENFQDH YCFFTPYYVK PDVPTFDDFV RGDPVAQKAA FDQWYSNKDG PLTTNGIEAG 

       370        380        390        400        410        420 
VKIRPTEEEL ATADEDFRRG YAEYFENKPD KPLMHYSVIS GFFGDHTKIP NGKFMTMFHF 

       430        440        450        460        470        480 
LEYPFSRGFV RITSANPYDA PDFDPGFLND ERDLWPMVWA YKKSRETARR MESFAGEVTS 

       490        500        510        520        530        540 
HHPLFKVDSP ARARDLDLET CSAYAGPKHL TANLYHGSWT VPIDKPTPKN DFHVTSNQVQ 

       550        560        570        580        590        600 
LHSDIEYTEE DDEAIVNYIK EHTETTWHCL GTCSMAPREG SKIAPKGGVL DARLNVYGVQ 

       610        620        630        640        650        660 
NLKVADLSVC PDNVGCNTYS TALTIGEKAA TLVAEDLGYS GSDLDMTIPN FRLGTYEETG 


LARF

P04841 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools