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UniProtKB/Swiss-Prot entry P05413


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FABPH_HUMAN
Primary accession number P05413
Secondary accession numbers Q5VV93 Q99957
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    June 16, 2009 (Entry version 101)
Name and origin of the protein
Protein name Fatty acid-binding protein, heart
Synonyms Heart-type fatty acid-binding protein
H-FABP
Muscle fatty acid-binding protein
M-FABP
Mammary-derived growth inhibitor
MDGI
Gene name
Name: FABP3
Synonyms: FABP11, MDGI
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=1710107 [NCBI, ExPASy, EBI, Israel, Japan]
Peeter R.A., Veerkamp J.H., Kanda T., Ono T., Geurts van Kessel A.;
"Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization.";
Biochem. J. 276:203-207(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
Hu Y.F., Ao X., Russo I.H., Russo J.;
"Molecular cloning of human mammary-derived growth inhibitor (MDGI) reveals that its expression is associated with breast differentiation, but not with cancer progression.";
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Wu X., Arlt M., Goodfellow P.J., Rottman J.N.;
"Genomic organization and complete nucleotide sequence of the human cardiac fatty acid binding protein gene (FABP3), and identification of a closely related genomic sequence.";
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 2-133.
PubMed=3421901 [NCBI, ExPASy, EBI, Israel, Japan]
Offner G.D., Brecher P., Sawlivich W.B., Costello C.E., Troxler R.F.;
"Characterization and amino acid sequence of a fatty acid-binding protein from human heart.";
Biochem. J. 252:191-198(1988).
[8]
PROTEIN SEQUENCE OF 2-133, AND SEQUENCE REVISION.
DOI=10.1007/BF00231376; PubMed=2266954 [NCBI, ExPASy, EBI, Israel, Japan]
Boerchers T., Hoejrup P., Nielsen S.U., Roepstorff P., Spener F., Knudsen J.;
"Revision of the amino acid sequence of human heart fatty acid-binding protein.";
Mol. Cell. Biochem. 98:127-133(1990).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 15-133.
TISSUE=Heart;
DOI=10.1007/BF00420939; PubMed=8262516 [NCBI, ExPASy, EBI, Israel, Japan]
Troxler R.F., Offner G.D., Jiang J.W., Wu B.L., Skare J.C., Milunsky A., Wyandt H.E.;
"Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33.";
Hum. Genet. 92:563-566(1993).
[10]
PROTEIN SEQUENCE OF 23-31; 46-53; 67-80; 98-107 AND 114-127, AND MASS SPECTROMETRY.
TISSUE=Fetal brain cortex;
Lubec G., Chen W.-Q., Sun Y.;
Submitted (DEC-2008) to UniProtKB.
[11]
PROTEIN SEQUENCE OF 32-39.
TISSUE=Heart;
DOI=10.1002/elps.11501601192; PubMed=7498159 [NCBI, ExPASy, EBI, Israel, Japan]
Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K.;
"The major protein expression profile and two-dimensional protein database of human heart.";
Electrophoresis 16:1160-1169(1995).
[12]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
PubMed=1526991 [NCBI, ExPASy, EBI, Israel, Japan]
Zanotti G., Scapin G., Spadon P., Veerkamp J.H., Sacchettini J.C.;
"Three-dimensional structure of recombinant human muscle fatty acid-binding protein.";
J. Biol. Chem. 267:18541-18550(1992).
[13]
X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) IN COMPLEX WITH C18 FATTY ACID.
DOI=10.1016/S0969-2126(00)00052-6; PubMed=7922029 [NCBI, ExPASy, EBI, Israel, Japan]
Young A.C.M., Scapin G., Kromminga A., Patel S.B., Veerkamp J.H., Sacchettini J.C.;
"Structural studies on human muscle fatty acid binding protein at 1.4-A resolution: binding interactions with three C18 fatty acids.";
Structure 2:523-534(1994).
[14]
STRUCTURE BY NMR.
DOI=10.1042/0264-6021:3540259; PubMed=11171102 [NCBI, ExPASy, EBI, Israel, Japan]
Luecke C., Rademacher M., Zimmerman A.W., van Moerkerk H.T.B., Veerkamp J.H., Rueterjans H.;
"Spin-system heterogeneities indicate a selected-fit mechanism in fatty acid binding to heart-type fatty acid-binding protein (H-FABP).";
Biochem. J. 354:259-266(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X56549; CAA39889.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y10255; CAA71305.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U57623; AAB02555.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U17081; AAC99800.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S67314; AAB29294.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006727; AAP35373.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL451070; CAH71850.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007021; AAH07021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00219684; -.
PIR S15432; FZHUC.
RefSeq NP_004093.1; -.
UniGene Hs.657242
3D structure databases
PDB
1G5W; NMR; -; A=2-133.[ExPASy / RCSB / EBI]
1HMR; X-ray; 1.40 A; A=2-133.[ExPASy / RCSB / EBI]
1HMS; X-ray; 1.40 A; A=2-133.[ExPASy / RCSB / EBI]
1HMT; X-ray; 1.40 A; A=2-133.[ExPASy / RCSB / EBI]
2HMB; X-ray; 2.10 A; A=2-133.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1G5W; -.
1HMR; -.
1HMS; -.
1HMT; -.
2HMB; -.
ModBase P05413.
Protein-protein interaction databases
IntAct P05413; 2.
PTM databases
PhosphoSite P05413; -.
2D gel databases
HSC-2DPAGE P05413; -.
REPRODUCTION-2DPAGE IPI00219684; -.
Organism-specific databases
GeneCards GC01M031633; -.
H-InvDB HIX0000353; -.
HGNC HGNC:3557; FABP3.
GenAtlas FABP3.
HPA CAB017830; -.
MIM 134651; gene. [NCBI / EBI]
PharmGKB PA27958; -.
Gene expression databases
ArrayExpress P05413; -.
Bgee P05413; -.
CleanEx HS_FABP3; -.
GermOnline ENSG00000121769; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008289; Molecular function: lipid binding (traceable author statement from ProtInc).
GO:0005215; Molecular function: transporter activity (inferred from electronic annotation from InterPro).
GO:0008285; Biological process: negative regulation of cell proliferation (traceable author statement from ProtInc).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012674; Calycin.
IPR000463; Fatty_acid_bd.
IPR000566; Lipocln_cytFABP.
Graphical view of domain structure.
Gene3D G3DSA:2.40.128.20; Calycin; 1.
PANTHER PTHR11955; Fatty_acid_bd; 1.
Pfam PF00061; Lipocalin; 1.
Pfam graphical view of domain structure.
PRINTS PR00178; FATTYACIDBP.
PROSITE PS00214; FABP; 1.
Proteomic databases
PeptideAtlas P05413; -.
PRIDE P05413; -.
Genome annotation databases
Ensembl ENSG00000121769; Homo sapiens. [Contig view]
GeneID 2170; -.
KEGG hsa:2170; -.
Phylogenomic databases
HOGENOM P05413; -.
HOVERGEN P05413; -.
OMA P05413; KWNGQET.
Other
NextBio 8763; -.
SOURCE FABP3; Homo sapiens.
ProtoNet P05413.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Cytoplasm; Direct protein sequencing; Lipid-binding; Phosphoprotein; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   133  132     Fatty acid-binding protein, heart. PRO_0000067321
BINDING   127   127        Fatty acid. 
BINDING   129   129        Fatty acid. 
MOD_RES   2     2        N-acetylvaline. 
MOD_RES   20    20        Phosphotyrosine; by Tyr-kinases (By similarity). 
CONFLICT   2     2        V -> A (in Ref. 2; CAA71305). 
CONFLICT   105   105        L -> K (in Ref. 7; AA sequence). 
CONFLICT   125   125        C -> S (in Ref. 7; AA sequence). 
CONFLICT   130   130        E -> Q (in Ref. 8; AA sequence). 
HELIX   3     5  3      
STRAND   7    16  10      
HELIX   17    24  8      
HELIX   28    34  7      
STRAND   40    46  7      
STRAND   49    55  7      
STRAND   61    65  5      
STRAND   71    74  4      
STRAND   80    88  9      
STRAND   91    98  8      
STRAND   101   110  10      
STRAND   113   120  8      
STRAND   123   131  9      
Sequence information
Length: 133 AA [This is the length of the unprocessed precursor] Molecular weight: 14858 Da [This is the MW of the unprocessed precursor] CRC64: 5FD396B1BE538A3C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL TLKTHSTFKN 

        70         80         90        100        110        120 
TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG QETTLVRELI DGKLILTLTH 

       130 
GTAVCTRTYE KEA 

P05413 in FASTA format

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