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UniProtKB/Swiss-Prot entry P05937


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CALB1_HUMAN
Primary accession number P05937
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 83)
Name and origin of the protein
Protein name Calbindin
Synonyms Vitamin D-dependent calcium-binding protein, avian-type
Calbindin D28
D-28K
Gene name
Name: CALB1
Synonyms: CAB27
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=3691519 [NCBI, ExPASy, EBI, Israel, Japan]
Parmentier M., Lawson D.E.M., Vassart G.;
"Human 27-kDa calbindin complementary DNA sequence. Evolutionary and functional implications.";
Eur. J. Biochem. 170:207-215(1987).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04406; PubMed=16421571 [NCBI, ExPASy, EBI, Israel, Japan]
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 201-261.
TISSUE=Brain;
DOI=10.1016/0888-7543(89)90335-2; PubMed=2565876 [NCBI, ExPASy, EBI, Israel, Japan]
Parmentier M., de Vijlder J.J.M., Muir E., Szpirer C., Islam M.Q., Geurts van Kessel A., Lawson D.E.M., Vassart G.;
"The human calbindin 27-kDa gene: structural organization of the 5' and 3' regions, chromosomal assignment, and restriction fragment length polymorphism.";
Genomics 4:309-319(1989).
[5]
INTERACTION WITH RANBP9.
DOI=10.1016/S0006-291X(03)00499-6; PubMed=12684061 [NCBI, ExPASy, EBI, Israel, Japan]
Lutz W., Frank E.M., Craig T.A., Thompson R., Venters R.A., Kojetin D., Cavanagh J., Kumar R.;
"Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy.";
Biochem. Biophys. Res. Commun. 303:1186-1192(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X06661; CAA29860.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF068862; AAC62230.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004612; AAC14672.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF049895; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC006478; AAH06478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC020864; AAH20864.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M19878; AAA98991.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M19879; AAA98992.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00234; S00234.
RefSeq NP_004920.1; -.
UniGene Hs.65425
3D structure databases
HSSP P02621; 1A75. [HSSP ENTRY / PDB]
SMR P05937; 1-261.
ModBase P05937.
PTM databases
PhosphoSite P05937; -.
Organism-specific databases
H-InvDB HIX0007639; -.
HGNC HGNC:1434; CALB1.
GenAtlas CALB1.
HPA CAB002138; -.
MIM 114050; gene. [NCBI / EBI]
PharmGKB PA26026; -.
GeneCards P05937.
Gene expression databases
ArrayExpress P05937; -.
CleanEx HS_CALB1; -.
GermOnline ENSG00000104327; Homo sapiens.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (traceable author statement from ProtInc).
GO:0005499; Molecular function: vitamin D binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011992; EF-Hand_type.
IPR002048; EF_hand_Ca_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.238.10; EF-Hand_type; 1.
Pfam PF00036; efhand; 4.
Pfam graphical view of domain structure.
ProDom PD000012; EF-hand; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00054; EFh; 4.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 4.
PS50222; EF_HAND_2; 5.
PROSITE graphical view of domain structure (profiles).
ProtoNet P05937.
Proteomic databases
PeptideAtlas P05937; -.
Genome annotation databases
Ensembl ENSG00000104327; Homo sapiens. [Contig view]
GeneID 793; -.
KEGG hsa:793; -.
Phylogenomic databases
HOGENOM P05937; -.
HOVERGEN P05937; -.
Other
NextBio 3218; -.
SOURCE CALB1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Calcium; Repeat; Vitamin D.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   261  260     Calbindin. PRO_0000073472
DOMAIN   11    46  36     EF-hand 1. 
DOMAIN   53    88  36     EF-hand 2. 
DOMAIN   98   133  36     EF-hand 3. 
DOMAIN   142   177  36     EF-hand 4. 
DOMAIN   186   221  36     EF-hand 5. 
CA_BIND   24    35  12     1. 
CA_BIND   111   122  12     2. 
CA_BIND   155   166  12     3. 
CA_BIND   199   210  12     4. 
REGION   2     7  6     Interaction with RANBP9. 
MOD_RES   2     2        N-acetylalanine (By similarity). 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 30025 Da [This is the MW of the unprocessed precursor] CRC64: 8ED7A09BCC5FE5E4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT 

        70         80         90        100        110        120 
FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET 

       130        140        150        160        170        180 
EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK 

       190        200        210        220        230        240 
FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA 

       250        260 
LSDGGKLYRT DLALILCAGD N 

P05937 in FASTA format

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View entry in raw text format (no links)
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