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UniProtKB/Swiss-Prot entry P07003


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name POXB_ECOLI
Primary accession number P07003
Secondary accession numbers Q47513 Q47514 Q47515 Q47516 Q47517 Q47518 Q47519 Q47520
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 88)
Name and origin of the protein
Protein name Pyruvate dehydrogenase [cytochrome]
Synonyms EC 1.2.2.2
Pyruvate oxidase
POX
Pyruvate dehydrogenase [Ubiquinone]
Contains Alpha-peptide
Gene name
Name: poxB
OrderedLocusNames: b0871, JW0855
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=K12;
DOI=10.1093/nar/14.13.5449; PubMed=3016647 [NCBI, ExPASy, EBI, Israel, Japan]
Grabau C., Cronan J.E. Jr.;
"Nucleotide sequence and deduced amino acid sequence of Escherichia coli pyruvate oxidase, a lipid-activated flavoprotein.";
Nucleic Acids Res. 14:5449-5460(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/dnares/3.3.137; PubMed=8905232 [NCBI, ExPASy, EBI, Israel, Japan]
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.;
"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.";
DNA Res. 3:137-155(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS.
STRAIN=K12;
PubMed=2663858 [NCBI, ExPASy, EBI, Israel, Japan]
Grabau C., Chang Y.Y., Cronan J.E. Jr.;
"Lipid binding by Escherichia coli pyruvate oxidase is disrupted by small alterations of the carboxyl-terminal region.";
J. Biol. Chem. 264:12510-12519(1989).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 550-572.
PubMed=3902830 [NCBI, ExPASy, EBI, Israel, Japan]
Recny M.A., Grabau C., Cronan J.E. Jr., Hager L.P.;
"Characterization of the alpha-peptide released upon protease activation of pyruvate oxidase.";
J. Biol. Chem. 260:14287-14291(1985).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
PubMed=8022274 [NCBI, ExPASy, EBI, Israel, Japan]
Chang Y.Y., Wang A.Y., Cronan J.E. Jr.;
"Expression of Escherichia coli pyruvate oxidase (PoxB) depends on the sigma factor encoded by the rpoS(katF) gene.";
Mol. Microbiol. 11:1019-1028(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X04105; CAA27725.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC73958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAA35585.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S73268; AAB31180.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M28208; AAB59101.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47688; AAB59102.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47689; AAB59103.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47690; AAB59104.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47691; AAB59105.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47692; AAB59106.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47693; AAB59107.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47694; AAB59108.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L47695; AAB59109.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A23648; DEECPC.
RefSeq AP_001502.1; -.
NP_415392.1; -.
3D structure databases
ModBase P07003.
Protein-protein interaction databases
IntAct P07003; -.
Enzyme and pathway databases
BioCyc EcoCyc:PYRUVOXID-MON; -.
MetaCyc:PYRUVOXID-MON; -.
2D gel databases
SWISS-2DPAGE P07003; -.
ECO2DBASE G058.0; 6TH EDITION.
Organism-specific databases
EchoBASE EB0747; -.
EcoGene EG10754; poxB.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000399; TPP_bd_CS.
IPR012001; TPP_bd_enzyme_N.
IPR011766; TPP_enzyme_bd_C.
IPR012000; TPP_enzyme_M.
Graphical view of domain structure.
Pfam PF02775; TPP_enzyme_C; 1.
PF00205; TPP_enzyme_M; 1.
PF02776; TPP_enzyme_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00187; TPP_ENZYMES; 1.
BLOCKS P07003.
Genome annotation databases
GeneID 946132; -.
GenomeReviews U00096_GR; b0871.
AP009048_GR; JW0855.
KEGG ecj:JW0855; -.
eco:b0871; -.
Other
DrugBank DB00336; Nitrofurazone.
Genome annotation databases
CMR P07003; b0871.
Other
ProtoNet P07003.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Lipid-binding; Magnesium; Membrane; Oxidoreductase; Thiamine pyrophosphate.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   572  572     Pyruvate dehydrogenase [cytochrome]. PRO_0000044606
PEPTIDE   550   572  23     Alpha-peptide. PRO_0000035665
MUTAGEN   533   533        A->T: In poxB11. 
MUTAGEN   549   572        Missing: In poxB6. 
MUTAGEN   553   553        A->V: In poxB14. 
MUTAGEN   560   560        D->P: In poxB15; normal activity. 
MUTAGEN   564   572        Missing: In poxB7. 
MUTAGEN   564   564        E->P: In poxB16; loss of activity. 
MUTAGEN   570   572        Missing: In poxB8. 
MUTAGEN   572   572        R->G: In poxB10; reduced activity; may interact less with membranes. 
CONFLICT   364   365        QQ -> HE (in Ref. 5; AAB59101/AAB59102). 
CONFLICT   414   416        QAL -> HGV (in Ref. 5; AAB59101/AAB59102). 
Sequence information
Length: 572 AA [This is the length of the unprocessed precursor] Molecular weight: 62011 Da [This is the MW of the unprocessed precursor] CRC64: 57B38B9E3A92BDEA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKQTVAAYIA KTLESAGVKR IWGVTGDSLN GLSDSLNRMG TIEWMSTRHE EVAAFAAGAE 

        70         80         90        100        110        120 
AQLSGELAVC AGSCGPGNLH LINGLFDCHR NHVPVLAIAA HIPSSEIGSG YFQETHPQEL 

       130        140        150        160        170        180 
FRECSHYCEL VSSPEQIPQV LAIAMRKAVL NRGVSVVVLP GDVALKPAPE GATMHWYHAP 

       190        200        210        220        230        240 
QPVVTPEEEE LRKLAQLLRY SSNIALMCGS GCAGAHKELV EFAGKIKAPI VHALRGKEHV 

       250        260        270        280        290        300 
EYDNPYDVGM TGLIGFSSGF HTMMNADTLV LLGTQFPYRA FYPTDAKIIQ IDINPASIGA 

       310        320        330        340        350        360 
HSKVDMALVG DIKSTLRALL PLVEEKADRK FLDKALEDYR DARKGLDDLA KPSEKAIHPQ 

       370        380        390        400        410        420 
YLAQQISHFA ADDAIFTCDV GTPTVWAARY LKMNGKRRLL GSFNHGSMAN AMPQALGAQA 

       430        440        450        460        470        480 
TEPERQVVAM CGDGGFSMLM GDFLSVVQMK LPVKIVVFNN SVLGFVAMEM KAGGYLTDGT 

       490        500        510        520        530        540 
ELHDTNFARI AEACGITGIR VEKASEVDEA LQRAFSIDGP VLVDVVVAKE ELAIPPQIKL 

       550        560        570 
EQAKGFSLYM LRAIISGRGD EVIELAKTNW LR 

P07003 in FASTA format

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