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UniProtKB/Swiss-Prot entry P07685


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_NEUCR
Primary accession number P07685
Secondary accession numbers O42788 O42789 Q7RVK0
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on June 7, 2005 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 83)
Name and origin of the protein
Protein name Histidine biosynthesis trifunctional protein
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphohydrolase
     (EC 3.6.1.31)
Histidinol dehydrogenase
     (HDH)
     (EC 1.1.1.23)
Gene name
Name: his-3
ORFNames: 5C2.120, NCU03139
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=74-OR23-1VA / FGSC 2489;
DOI=10.1016/0378-1119(85)90306-3; PubMed=3005109 [NCBI, ExPASy, EBI, Israel, Japan]
Legerton T.L., Yanofsky C.;
"Cloning and characterization of the multifunctional his-3 gene of Neurospora crassa.";
Gene 39:129-140(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-44; VAL-50; PRO-410; ASN-708 AND MET-726.
STRAIN=74-OR23-1VA / FGSC 2489, and FGSC 541;
Yeadon P.J., Petersen A., Catcheside D.E.A.;
"DNA sequence of histidine-3 from two Neurospora wild-types.";
Fungal Genet. Newsl. 45:43-43(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M27531; AAA33588.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF045455; AAC02221.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF045456; AAC02222.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX842637; CAE76555.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000009; EAA34952.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A23978; SHNC.
RefSeq XP_964188.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase P07685.
Family and domain databases
InterPro IPR016298; Histidine_synth_trifunct.
IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001257; His_trifunctional; 1.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
TIGR03188; histidine_hisI; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS P07685.
Genome annotation databases
GeneID 3880337; -.
KEGG ncr:NCU03139; -.
NMPDR fig|5141.1.peg.8508; -.
Other
ProtoNet P07685.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Metal-binding; Multifunctional enzyme; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   870  870     Histidine biosynthesis trifunctional protein. PRO_0000135911
REGION   1   285  285     Phosphoribosyl-AMP cyclohydrolase. 
REGION   286   367  82     Phosphoribosyl-ATP pyrophosphohydrolase. 
REGION   368   870  503     Histidinol dehydrogenase. 
ACT_SITE   762   762        By similarity. 
ACT_SITE   763   763        By similarity. 
METAL   693   693        Zinc (By similarity). 
METAL   696   696        Zinc (By similarity). 
METAL   796   796        Zinc (By similarity). 
METAL   855   855        Zinc (By similarity). 
VARIANT   44    44  1     Q -> K (in strain: FGSC 541). 
VARIANT   50    50  1     L -> V (in strain: FGSC 541). 
VARIANT   410   410  1     L -> P (in strain: FGSC 541). 
VARIANT   708   708  1     D -> N (in strain: FGSC 541). 
VARIANT   726   726  1     T -> M (in strain: FGSC 541). 
CONFLICT   604   604        Y -> H (in Ref. 2; AAC02221/AAC02222). 
CONFLICT   811   811        A -> G (in Ref. 2; AAC02221/AAC02222). 
CONFLICT   819   819        L -> F (in Ref. 2; AAC02221). 
Sequence information
Length: 870 AA [This is the length of the unprocessed precursor] Molecular weight: 93836 Da [This is the MW of the unprocessed precursor] CRC64: ACE28C977682E120 [This is a checksum on the sequence]
        10         20         30         40         50         60 
METTLPLPFL VGVSVPPGLN DIKEGLSREE VSCLGCVFFE VKPQTLEKIL RFLKRHNVEF 

        70         80         90        100        110        120 
EPYFDVTALE SIDDIITLLD AGARKVFVKT EQLADLSAYG SRVAPIVTGS SAALLSSATE 

       130        140        150        160        170        180 
SGLLLSGFDQ TASEAAQFLE EARDKKITPF FIKPVPGADL EQFIQVAAKA NAIPILPSTG 

       190        200        210        220        230        240 
LTTKKDEAGK LAISTILSSV WKSDRPDGLL PTVVVDEHDT ALGLVYSSAE SVNEALRTQT 

       250        260        270        280        290        300 
GVYQSRKRGL WYKGATSGDT QELVRISLDC DNDALKFVVK QKGRFCHLDQ SGCFGQLKGL 

       310        320        330        340        350        360 
PKLEQTLISR KQSAPEGSYT ARLFSDEKLV RAKIMEEAEE LCTAQTPQEI AFEAADLFYF 

       370        380        390        400        410        420 
ALTRAVAAGV TLADIERSLD AKSWKVKRRT GDAKGKWAEK EGIKPAASAL AATSAPVTKE 

       430        440        450        460        470        480 
AAQETTPEKI TMRRFDASKV STEELDAALK RPAQKSSDAI YKIIVPIIED VRKNGDKAVL 

       490        500        510        520        530        540 
SYTHKFEKAT SLTSPVLKAP FPKELMQLPE ETIAAIDVSF ENIRKFHAAQ KEEKPLQVET 

       550        560        570        580        590        600 
MPGVVCSRFS RPIEAVGCYI PGGTAVLPST ALMLGVPAMV AGCNKIVFAS PPRADGTITP 

       610        620        630        640        650        660 
EIVYVAHKVG AESIVLAGGA QAVAAMAYGT ESITKVDKIL GPGNQFVTAA KMFVSNDTNA 

       670        680        690        700        710        720 
AVGIDMPAGP SEVLVIADKD ANPAFVASDL LSQAEHGVDS QVILIAIDLD EEHLQAIEDE 

       730        740        750        760        770        780 
VHRQATELPR VQIVRGSIAH SITVQVKTVE EAMELSNKYA PEHLILQIKE AEKAVDLVMN 

       790        800        810        820        830        840 
AGSVFIGAWT PESVGDYSAG VNHSLPTYGF AKQYSGVNLA SFVKHITSSN LTAEGLKNVG 

       850        860        870 
QAVMQLAKVE ELEAHRRAVS IRLEHMSKSN 

P07685 in FASTA format

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