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UniProtKB/Swiss-Prot entry P08566


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARO1_YEAST
Primary accession number P08566
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 96)
Name and origin of the protein
Protein name Pentafunctional AROM polypeptide
Synonyms None
Includes 3-dehydroquinate synthase
     (EC 4.2.3.4)
3-phosphoshikimate 1-carboxyvinyltransferase
     (EC 2.5.1.19)
     (5-enolpyruvylshikimate-3-phosphate synthase)
     (EPSP synthase)
     (EPSPS)
Shikimate kinase
     (EC 2.7.1.71)
3-dehydroquinate dehydratase
     (3-dehydroquinase)
     (EC 4.2.1.10)
Shikimate dehydrogenase
     (EC 1.1.1.25)
Gene name
Name: ARO1
Synonyms: AROM
OrderedLocusNames: YDR127W
ORFNames: YD9302.02
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2825635 [NCBI, ExPASy, EBI, Israel, Japan]
Duncan K., Edwards R.M., Coggins J.R.;
"The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains.";
Biochem. J. 246:375-386(1987).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169867 [NCBI, ExPASy, EBI, Israel, Japan]
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
Nature 387:75-78(1997).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44 AND 1557-1588.
DOI=10.1016/0014-5793(88)81036-6; PubMed=2848727 [NCBI, ExPASy, EBI, Israel, Japan]
Duncan K., Edwards R.M., Coggins J.R.;
"The Saccharomyces cerevisiae ARO1 gene. An example of the co-ordinate regulation of five enzymes on a single biosynthetic pathway.";
FEBS Lett. 241:83-88(1988).
[4]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X06077; CAA29458.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z48179; CAA88208.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X13802; CAA32036.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X13803; CAA32037.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A32519; BVBYA1.
RefSeq NP_010412.1; -.
3D structure databases
HSSP P07547; 1NUA. [HSSP ENTRY / PDB]
ModBase P08566.
Protein-protein interaction databases
DIP DIP:2611N; -.
IntAct P08566; -.
Organism-specific databases
CYGD YDR127w; -.
SGD S000002534; ARO1.
Yeast-GFP YDR127W.
Gene expression databases
ArrayExpress P08566; -.
GermOnline YDR127W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from SGD).
GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity (inferred from direct assay from SGD).
GO:0003856; Molecular function: 3-dehydroquinate synthase activity (inferred from direct assay from SGD).
GO:0003866; Molecular function: 3-phosphoshikimate 1-carboxyvinyltransferase activity (inferred from direct assay from SGD).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from direct assay from SGD).
GO:0004765; Molecular function: shikimate kinase activity (inferred from direct assay from SGD).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR002658; DHQ_synth_AroB.
IPR016037; DHQ_synth_AroB_sub.
IPR001381; DHquinase_I.
IPR001986; EPSP_synthase_core.
IPR006264; EPSP_synthase_subgroup.
IPR008289; Pentafunct_AroM.
IPR010110; Shik_DHase_AROM.
IPR000623; Shik_kinase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:3.65.10.10; EPSP_synthase; 1.
PANTHER PTHR21090:SF1; DHQ_synth_AroB; 1.
Pfam PF01761; DHQ_synthase; 1.
PF01487; DHquinase_I; 1.
PF00275; EPSP_synthase; 1.
PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
PF01202; SKI; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000514; Pentafunct_AroM; 1.
PRINTS PR01100; SHIKIMTKNASE.
ProDom PD005337; DHquinase_I; 1.
PD001867; EPSP_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01356; aroA; 1.
TIGR01357; aroB; 1.
TIGR01093; aroD; 1.
TIGR01809; Shik-DH-AROM; 1.
PROSITE PS01028; DEHYDROQUINASE_I; 1.
PS00104; EPSP_SYNTHASE_1; 1.
PS00885; EPSP_SYNTHASE_2; 1.
PS01128; SHIKIMATE_KINASE; 1.
BLOCKS P08566.
Proteomic databases
PeptideAtlas P08566; -.
Genome annotation databases
Ensembl YDR127W; Saccharomyces cerevisiae. [Contig view]
GeneID 851705; -.
GenomeReviews Z71256_GR; YDR127W.
KEGG sce:YDR127W; -.
NMPDR fig|4932.3.peg.1161; -.
Phylogenomic databases
HOGENOM P08566; -.
Other
LinkHub P08566; -.
ProtoNet P08566.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Lyase; Multifunctional enzyme; NADP; Nucleotide-binding; Oxidoreductase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1588  1588     Pentafunctional AROM polypeptide. PRO_0000140862
NP_BIND   895    902  8     ATP (By similarity). 
REGION   1    392  392     3-dehydroquinate synthase. 
REGION   404    866  463     EPSP synthase. 
REGION   887   1060  174     Shikimate kinase. 
REGION   1061   1293  233     3-dehydroquinase. 
REGION   1306   1588  283     Shikimate dehydrogenase. 
ACT_SITE   853    853        Potential. 
ACT_SITE   1198   1198        Proton acceptor (By similarity). 
ACT_SITE   1227   1227        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 1588 AA [This is the length of the unprocessed precursor] Molecular weight: 174755 Da [This is the MW of the unprocessed precursor] CRC64: 9880EE2423CDE410 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVQLAKVPIL GNDIIHVGYN IHDHLVETII KHCPSSTYVI CNDTNLSKVP YYQQLVLEFK 

        70         80         90        100        110        120 
ASLPEGSRLL TYVVKPGETS KSRETKAQLE DYLLVEGCTR DTVMVAIGGG VIGDMIGFVA 

       130        140        150        160        170        180 
STFMRGVRVV QVPTSLLAMV DSSIGGKTAI DTPLGKNFIG AFWQPKFVLV DIKWLETLAK 

       190        200        210        220        230        240 
REFINGMAEV IKTACIWNAD EFTRLESNAS LFLNVVNGAK NVKVTNQLTN EIDEISNTDI 

       250        260        270        280        290        300 
EAMLDHTYKL VLESIKVKAE VVSSDERESS LRNLLNFGHS IGHAYEAILT PQALHGECVS 

       310        320        330        340        350        360 
IGMVKEAELS RYFGILSPTQ VARLSKILVA YGLPVSPDEK WFKELTLHKK TPLDILLKKM 

       370        380        390        400        410        420 
SIDKKNEGSK KKVVILESIG KCYGDSAQFV SDEDLRFILT DETLVYPFKD IPADQQKVVI 

       430        440        450        460        470        480 
PPGSKSISNR ALILAALGEG QCKIKNLLHS DDTKHMLTAV HELKGATISW EDNGETVVVE 

       490        500        510        520        530        540 
GHGGSTLSAC ADPLYLGNAG TASRFLTSLA ALVNSTSSQK YIVLTGNARM QQRPIAPLVD 

       550        560        570        580        590        600 
SLRANGTKIE YLNNEGSLPI KVYTDSVFKG GRIELAATVS SQYVSSILMC APYAEEPVTL 

       610        620        630        640        650        660 
ALVGGKPISK LYVDMTIKMM EKFGINVETS TTEPYTYYIP KGHYINPSEY VIESDASSAT 

       670        680        690        700        710        720 
YPLAFAAMTG TTVTVPNIGF ESLQGDARFA RDVLKPMGCK ITQTATSTTV SGPPVGTLKP 

       730        740        750        760        770        780 
LKHVDMEPMT DAFLTACVVA AISHDSDPNS ANTTTIEGIA NQRVKECNRI LAMATELAKF 

       790        800        810        820        830        840 
GVKTTELPDG IQVHGLNSIK DLKVPSDSSG PVGVCTYDDH RVAMSFSLLA GMVNSQNERD 

       850        860        870        880        890        900 
EVANPVRILE RHCTGKTWPG WWDVLHSELG AKLDGAEPLE CTSKKNSKKS VVIIGMRAAG 

       910        920        930        940        950        960 
KTTISKWCAS ALGYKLVDLD ELFEQQHNNQ SVKQFVVENG WEKFREEETR IFKEVIQNYG 

       970        980        990       1000       1010       1020 
DDGYVFSTGG GIVESAESRK ALKDFASSGG YVLHLHRDIE ETIVFLQSDP SRPAYVEEIR 

      1030       1040       1050       1060       1070       1080 
EVWNRREGWY KECSNFSFFA PHCSAEAEFQ ALRRSFSKYI ATITGVREIE IPSGRSAFVC 

      1090       1100       1110       1120       1130       1140 
LTFDDLTEQT ENLTPICYGC EAVEVRVDHL ANYSADFVSK QLSILRKATD SIPIIFTVRT 

      1150       1160       1170       1180       1190       1200 
MKQGGNFPDE EFKTLRELYD IALKNGVEFL DLELTLPTDI QYEVINKRGN TKIIGSHHDF 

      1210       1220       1230       1240       1250       1260 
QGLYSWDDAE WENRFNQALT LDVDVVKFVG TAVNFEDNLR LEHFRDTHKN KPLIAVNMTS 

      1270       1280       1290       1300       1310       1320 
KGSISRVLNN VLTPVTSDLL PNSAAPGQLT VAQINKMYTS MGGIEPKELF VVGKPIGHSR 

      1330       1340       1350       1360       1370       1380 
SPILHNTGYE ILGLPHKFDK FETESAQLVK EKLLDGNKNF GGAAVTIPLK LDIMQYMDEL 

      1390       1400       1410       1420       1430       1440 
TDAAKVIGAV NTVIPLGNKK FKGDNTDWLG IRNALINNGV PEYVGHTAGL VIGAGGTSRA 

      1450       1460       1470       1480       1490       1500 
ALYALHSLGC KKIFIINRTT SKLKPLIESL PSEFNIIGIE STKSIEEIKE HVGVAVSCVP 

      1510       1520       1530       1540       1550       1560 
ADKPLDDELL SKLERFLVKG AHAAFVPTLL EAAYKPSVTP VMTISQDKYQ WHVVPGSQML 

      1570       1580 
VHQGVAQFEK WTGFKGPFKA IFDAVTKE 

P08566 in FASTA format

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