[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-252.
TISSUE=Liver;
PubMed=3460094 [NCBI, ExPASy, EBI, Israel, Japan]
Molowa D.T.,
Schuetz E.G.,
Wrighton S.A.,
Watkins P.B.,
Kremers P.,
Mendez-Picon G.,
Parker G.A.,
Guzelian P.S.;
"Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.";
Proc. Natl. Acad. Sci. U.S.A. 83:5311-5315(1986).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3267210 [NCBI, ExPASy, EBI, Israel, Japan]
Gonzalez F.J.,
Schmid B.J.,
Umeno M.,
McBride O.W.,
Hardwick J.P.,
Meyer U.A.,
Gelboin H.V.,
Idle J.R.;
"Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.";
DNA 7:79-86(1988).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-431.
PubMed=3464943 [NCBI, ExPASy, EBI, Israel, Japan]
Beaune P.H.,
Umbenhauer D.R.,
Bork R.W.,
Lloyd R.S.,
Guengerich F.P.;
"Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.";
Proc. Natl. Acad. Sci. U.S.A. 83:8064-8068(1986).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/BF00293896; PubMed=2563251 [NCBI, ExPASy, EBI, Israel, Japan]
Spurr N.K.,
Gough A.C.,
Stevenson K.,
Wolf C.R.;
"The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.";
Hum. Genet. 81:171-174(1989).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-431.
TISSUE=Liver;
PubMed=2463251 [NCBI, ExPASy, EBI, Israel, Japan]
Bork R.W.,
Muto T.,
Beaune P.H.,
Srivastava P.K.,
Lloyd R.S.,
Guengerich F.P.;
"Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.";
J. Biol. Chem. 264:910-919(1989).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=10322772 [NCBI, ExPASy, EBI, Israel, Japan]
Chen Q.,
Wu J.,
Yu Y.;
"Establishment of transgenic cell line CHL-3A4 and its metabolic activation.";
Zhonghua Yu Fang Yi Xue Za Zhi 32:281-284(1998).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1097/00008571-200103000-00002; PubMed=11266076 [NCBI, ExPASy, EBI, Israel, Japan]
Gellner K.,
Eiselt R.,
Hustert E.,
Arnold H.,
Koch I.,
Haberl M.,
Deglmann C.J.,
Burk O.,
Buntefuss D.,
Escher S.,
Bishop C.,
Koebe H.-G.,
Brinkmann U.,
Klenk H.-P.,
Kleine K.,
Meyer U.A.,
Wojnowski L.;
"Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.";
Pharmacogenetics 11:111-121(2001).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-118 AND ARG-218.
PubMed=11181494 [NCBI, ExPASy, EBI, Israel, Japan]
Hsieh K.-P.,
Lin Y.-Y.,
Cheng C.-L.,
Lai M.-L.,
Lin M.-S.,
Siest J.-P.,
Huang J.-D.;
"Novel mutations of CYP3A4 in Chinese.";
Drug Metab. Dispos. 29:268-273(2001).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Zhuge J.,
Qian Y.,
Xie H.,
Yu Y.;
"Sequence of a new human cytochrome P450-3A4 cDNA.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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[10]
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PROTEIN SEQUENCE OF 2-25.
PubMed=3243766 [NCBI, ExPASy, EBI, Israel, Japan]
Komori M.,
Hashizume T.,
Ohi H.,
Miura T.,
Kitada M.,
Nagashima K.,
Kamataki T.;
"Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.";
J. Biochem. 104:912-916(1988).
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[11]
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PROTEIN SEQUENCE OF 2-21.
TISSUE=Liver;
PubMed=3898085 [NCBI, ExPASy, EBI, Israel, Japan]
Watkins P.B.,
Wrighton S.A.,
Maurel P.,
Schuetz E.G.,
Mendez-Picon G.,
Parker G.A.,
Guzelian P.S.;
"Identification of an inducible form of cytochrome P-450 in human liver.";
Proc. Natl. Acad. Sci. U.S.A. 82:6310-6314(1985).
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[12]
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CHARACTERIZATION.
PubMed=9088578 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H.,
Coville P.F.,
Walker R.J.,
Miners J.O.,
Birkett D.J.,
Wanwimolruk S.;
"Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.";
Br. J. Clin. Pharmacol. 43:245-252(1997).
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[13]
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CHARACTERIZATION.
PubMed=9456308 [NCBI, ExPASy, EBI, Israel, Japan]
Zhao X.J.,
Kawashiro T.,
Ishizaki T.;
"Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.";
Drug Metab. Dispos. 26:188-191(1998).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 24-503.
DOI=10.1074/jbc.C400293200; PubMed=15258162 [NCBI, ExPASy, EBI, Israel, Japan]
Yano J.K.,
Wester M.R.,
Schoch G.A.,
Griffin K.J.,
Stout C.D.,
Johnson E.F.;
"The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.";
J. Biol. Chem. 279:38091-38094(2004).
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[15]
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X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 25-503.
DOI=10.1126/science.1099736; PubMed=15256616 [NCBI, ExPASy, EBI, Israel, Japan]
Williams P.A.,
Cosme J.,
Vinkovic D.M.,
Ward A.,
Angove H.C.,
Day P.J.,
Vonrhein C.,
Tickle I.J.,
Jhoti H.;
"Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.";
Science 305:683-686(2004).
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[16]
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VARIANTS PRO-222 AND THR-445.
DOI=10.1067/mcp.2000.104391; PubMed=10668853 [NCBI, ExPASy, EBI, Israel, Japan]
Sata F.,
Sapone A.,
Elizondo G.,
Stocker P.,
Miller V.P.,
Zheng W.,
Raunio H.,
Crespi C.L.,
Gonzalez F.J.;
"CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.";
Clin. Pharmacol. Ther. 67:48-56(2000).
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[17]
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VARIANTS GLN-162; SER-189; PRO-293; THR-445 AND SER-467, AND CHARACTERIZATION OF THE VARIANTS.
PubMed=11714865 [NCBI, ExPASy, EBI, Israel, Japan]
Dai D.,
Tang J.,
Rose R.,
Hodgson E.,
Bienstock R.J.,
Mohrenweiser H.W.,
Goldstein J.A.;
"Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.";
J. Pharmacol. Exp. Ther. 299:825-831(2001).
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[18]
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VARIANTS ASP-56; GLN-130; ILE-170; HIS-174; MET-363; PHE-373 AND LEU-416.
DOI=10.1097/00008571-200107000-00008; PubMed=11470997 [NCBI, ExPASy, EBI, Israel, Japan]
Eiselt R.,
Domanski T.L.,
Zibat A.,
Mueller R.,
Presecan-Siedel E.,
Hustert E.,
Zanger U.M.,
Brockmoller J.,
Klenk H.-P.,
Meyer U.A.,
Khan K.K.,
He Y.-A.,
Halpert J.R.,
Wojnowski L.;
"Identification and functional characterization of eight CYP3A4 protein variants.";
Pharmacogenetics 11:447-458(2001).
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[19]
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VARIANTS PRO-15; GLN-162; HIS-174; SER-185 AND PHE-373.
DOI=10.1097/00008571-200203000-00006; PubMed=11875366 [NCBI, ExPASy, EBI, Israel, Japan]
Lamba J.K.,
Lin Y.S.,
Thummel K.,
Daly A.,
Watkins P.B.,
Strom S.,
Zhang J.,
Schuetz E.G.;
"Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.";
Pharmacogenetics 12:121-132(2002).
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[20]
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VARIANTS HIS-174; SER-185 AND PRO-293.
DOI=10.1517/14622416.5.7.895; PubMed=15469410 [NCBI, ExPASy, EBI, Israel, Japan]
Solus J.F.,
Arietta B.J.,
Harris J.R.,
Sexton D.P.,
Steward J.Q.,
McMunn C.,
Ihrie P.,
Mehall J.M.,
Edwards T.L.,
Dawson E.P.;
"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.";
Pharmacogenomics 5:895-931(2004).
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