[1]
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NUCLEOTIDE SEQUENCE.
Yenofsky R.L.,
Fine M.,
Liu C.;
"Isolation and characterization of a soybean (Glycine max) lipoxygenase-3 gene.";
Mol. Gen. Genet. 211:215-222(1988).
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[2]
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SEQUENCE REVISION.
Yenofsky R.L.;
Submitted (DEC-1988) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE, AND MUTAGENESIS OF ASN-713.
STRAIN=cv. Provar;
DOI=10.1021/bi00254a010; PubMed=7999759 [NCBI, ExPASy, EBI, Israel, Japan]
Kramer J.A.,
Johnson K.R.,
Dunham W.R.,
Sands R.H.,
Funk M.O. Jr.;
"Position 713 is critical for catalysis but not iron binding in soybean lipoxygenase 3.";
Biochemistry 33:15017-15022(1994).
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[4]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
STRAIN=cv. Provar;
DOI=10.1002/(SICI)1097-0134(199709)29:1<15::AID-PROT2>3.3.CO;2-F; PubMed=9294864 [NCBI, ExPASy, EBI, Israel, Japan]
Skrzypczak-Jankun E.,
Amzel L.M.,
Kroa B.A.,
Funk M.O. Jr.;
"Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme.";
Proteins 29:15-31(1997).
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[5]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
STRAIN=cv. Provar;
DOI=10.1021/bi981989t; PubMed=9922163 [NCBI, ExPASy, EBI, Israel, Japan]
Pham C.,
Jankun J.,
Skrzypczak-Jankun E.,
Flowers R.A.,
Funk M.O. Jr.;
"Structural and thermochemical characterization of lipoxygenase-catechol complexes.";
Biochemistry 37:17952-17957(1998).
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[6]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH IRON IONS AND SUBSTRATE.
STRAIN=cv. Provar;
DOI=10.1021/ja011759t; PubMed=11686682 [NCBI, ExPASy, EBI, Israel, Japan]
Skrzypczak-Jankun E.,
Bross R.A.,
Carroll R.T.,
Dunham W.R.,
Funk M.O. Jr.;
"Three-dimensional structure of a purple lipoxygenase.";
J. Am. Chem. Soc. 123:10814-10820(2001).
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[7]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH IRON IONS AND CURCUMIN.
PubMed=12792803 [NCBI, ExPASy, EBI, Israel, Japan]
Skrzypczak-Jankun E.,
Zhou K.,
McCabe N.P.,
Selman S.H.,
Jankun J.;
"Structure of curcumin in complex with lipoxygenase and its significance in cancer.";
Int. J. Mol. Med. 12:17-24(2003).
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[8]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH IRON IONS AND THE INHIBITOR EPIGALLO-CATECHIN.
PubMed=12964012 [NCBI, ExPASy, EBI, Israel, Japan]
Skrzypczak-Jankun E.,
Zhou K.,
Jankun J.;
"Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.";
Int. J. Mol. Med. 12:415-420(2003).
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[9]
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X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH IRON IONS AND 4-NITROCATECHOL.
DOI=10.1107/S0907444904000861; PubMed=14993710 [NCBI, ExPASy, EBI, Israel, Japan]
Skrzypczak-Jankun E.,
Borbulevych O.Y.,
Jankun J.;
"Soybean lipoxygenase-3 in complex with 4-nitrocatechol.";
Acta Crystallogr. D 60:613-615(2004).
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[10]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH IRON IONS AND PROTOCATECHUIC ACID.
DOI=10.1002/prot.10579; PubMed=14705020 [NCBI, ExPASy, EBI, Israel, Japan]
Borbulevych O.Y.,
Jankun J.,
Selman S.H.,
Skrzypczak-Jankun E.;
"Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution.";
Proteins 54:13-19(2004).
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- FUNCTION: Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure.
- CATALYTIC ACTIVITY: Linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
- COFACTOR: Binds 1 iron ion per subunit. Iron is tightly bound (By similarity).
- PATHWAY: Lipid metabolism; oxylipin biosynthesis.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Cytoplasm.
- MISCELLANEOUS: Soybean contains at least 4 distinct isoenzymes, L-1, L-2, L-3a and L-3b in dry seeds, and at least two distinct isozymes in the hypocotyl/radicle region of the seedling stem.
- SIMILARITY: Belongs to the lipoxygenase family.
- SIMILARITY: Contains 1 PLAT domain.
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