ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P0A017


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name DYR_STAAU
Primary accession number P0A017
Secondary accession number P10167
Integrated into Swiss-Prot on March 1, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Dihydrofolate reductase
Synonyms DHFR
EC 1.5.1.3
Gene name
Name: folA
From
Staphylococcus aureus [TaxID: 1280] 
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 25923 / DSM 1104 / Seattle 1945 / FO 14462 / JCM 2413;
PubMed=8363365 [NCBI, ExPASy, EBI, Israel, Japan]
Dale G.E., Then R.L., Stueber D.;
"Characterization of the gene for chromosomal trimethoprim-sensitive dihydrofolate reductase of Staphylococcus aureus ATCC 25923.";
Antimicrob. Agents Chemother. 37:1400-1405(1993).
[2]
PROTEIN SEQUENCE OF 2-36.
STRAIN=157/4696;
DOI=10.1016/0014-5793(88)81006-8; PubMed=3060373 [NCBI, ExPASy, EBI, Israel, Japan]
Hartman P.G., Stahli M., Kocher H.P., Then R.L.;
"N-terminal amino acid sequence of the chromosomal dihydrofolate reductase purified from trimethoprim-resistant Staphylococcus aureus.";
FEBS Lett. 242:157-160(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z16422; CAA78910.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S32014; S32014.
3D structure databases
HSSP P00379; 1DHI. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase P0A017.
Family and domain databases
InterPro IPR012259; DHFR.
IPR001796; DHFR_reg.
Graphical view of domain structure.
PANTHER PTHR11549:SF1; DHFR; 1.
Pfam PF00186; DHFR_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00070; DHFR.
PROSITE PS00075; DHFR_1; 1.
PS51330; DHFR_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P0A017.
Other
BindingDB P0A017; -.
ProtoNet P0A017.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; NADP; One-carbon metabolism; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   159  158     Dihydrofolate reductase. PRO_0000186411
DOMAIN   2   157  156     DHFR. 
Sequence information
Length: 159 AA [This is the length of the unprocessed precursor] Molecular weight: 18251 Da [This is the MW of the unprocessed precursor] CRC64: 811898409FEAFAAB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTLSILVAHD LQRVIGFENQ LPWHLPNDLK HVKKLSTGHT LVMGRKTFES IGKPLPNRRN 

        70         80         90        100        110        120 
VVLTSDTSFN VEGVDVIHSI EDIYQLPGHV FIFGGQTLFE EMIDKVDDMY ITVIEGKFRG 

       130        140        150 
DTFFPPYTFE DWEVASSVEG KLDEKNTIPH TFLHLIRKK 

P0A017 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!