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UniProtKB/Swiss-Prot entry P0AEN3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRE_ECO57
Primary accession number P0AEN3
Secondary accession numbers P23486 P76768
Integrated into Swiss-Prot on December 20, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name NAD(P)H-flavin reductase
Synonyms EC 1.5.1.29
EC 1.16.1.3
FMN reductase
NAD(P)H:flavin oxidoreductase
Aquacobalamin reductase
Ferrisiderophore reductase C
Gene name
Name: fre
Synonyms: ubiB
OrderedLocusNames: Z5365, ECs4772
From
Escherichia coli O157:H7 [TaxID: 83334] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
DOI=10.1038/35054089; PubMed=11206551 [NCBI, ExPASy, EBI, Israel, Japan]
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.;
"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
Nature 409:529-533(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
DOI=10.1093/dnares/8.1.11; PubMed=11258796 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S., Shiba T., Hattori M., Shinagawa H.;
"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.";
DNA Res. 8:11-22(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005174; AAG59038.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000007; BAB38195.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B86072; B86072.
D91225; D91225.
RefSeq NP_290474.1; -.
NP_312799.1; -.
3D structure databases
SMR P0AEN3; 2-233.
ModBase P0AEN3.
Enzyme and pathway databases
BioCyc ECOL83334:ECS4772-MON; -.
Family and domain databases
InterPro IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
IPR001221; Phe_hydroxylase.
Graphical view of domain structure.
Pfam PF00970; FAD_binding_6; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00410; PHEHYDRXLASE.
PROSITE PS51384; FAD_FR; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P0AEN3.
Genome annotation databases
GeneID 915131; -.
960316; -.
GenomeReviews BA000007_GR; ECs4772.
AE005174_GR; Z5365.
KEGG ece:Z5365; -.
ecs:ECs4772; -.
Phylogenomic databases
HOGENOM P0AEN3; -.
Genome annotation databases
CMR P0AEN3; Z5365.
Other
ProtoNet P0AEN3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; FMN; Ion transport; Iron; Iron transport; NAD; NADP; Oxidoreductase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   233  232     NAD(P)H-flavin reductase. PRO_0000068145
DOMAIN   2    99  98     FAD-binding FR-type. 
NP_BIND   111   115  5     Pyridine (By similarity). 
Sequence information
Length: 233 AA [This is the length of the unprocessed precursor] Molecular weight: 26242 Da [This is the MW of the unprocessed precursor] CRC64: 0E64DE5A8FA0F12D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTLSCKVTS VEAITDTVYR VRIVPDAAFS FRAGQYLMVV MDERDKRPFS MASTPDEKGF 

        70         80         90        100        110        120 
IELHIGASEI NLYAKAVMDR ILKDHQIVVD IPHGEAWLRD DEERPMILIA GGTGFSYARS 

       130        140        150        160        170        180 
ILLTALARNP NRDITIYWGG REEQHLYDLC ELEALSLKHP GLQVVPVVEQ PEAGWRGRTG 

       190        200        210        220        230 
TVLTAVLQDH GTLAEHDIYI AGRFEMAKIA RDLFCSERNA REDRLFGDAF AFI
P0AEN3 in FASTA format

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