EC 1.6.1.2
Nicotinamide nucleotide transhydrogenase subunit alpha 2
Pyridine nucleotide transhydrogenase subunit alpha 2
Proton-translocating transhydrogenase component 2
dII

Gene name

	Name:	pntAB
	Synonyms:	nntA2

From

Rhodospirillum rubrum

[TaxID: 1085]

Taxonomy

Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; Rhodospirillaceae; Rhodospirillum.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/BF00762784; PubMed=7844118 [NCBI, ExPASy, EBI, Israel, Japan]
Yamaguchi M., Hatefi Y.;
"Energy-transducing nicotinamide nucleotide transhydrogenase: nucleotide sequences of the genes and predicted amino acid sequences of the subunits of the enzyme from Rhodospirillum rubrum.";
J. Bioenerg. Biomembr. 26:435-445(1994).

Comments

FUNCTION: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity).
CATALYTIC ACTIVITY: NADPH + NAD⁺ = NADP⁺ + NADH.
SUBUNIT: Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits.
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U01158; AAC43256.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P0C187.

Ontologies

GO:0055114;	Biological process: oxidation reduction (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Membrane; NAD; NADP; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 139`	`139`	`NAD(P) transhydrogenase subunit alpha part 2.`	`PRO_0000199021`
`TRANSMEM`	`49 69`	`21`	`Potential.`
`TRANSMEM`	`78 98`	`21`	`Potential.`
`TRANSMEM`	`107 127`	`21`	`Potential.`

Sequence information

Length: 139 AA [This is the length of the unprocessed precursor]

Molecular weight: 14889 Da [This is the MW of the unprocessed precursor]

CRC64: 04742D87817A8879 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEDKNILVEG FNQLSQQALE LSQHAQALAL QASHAVLPAA AATEGASEFW WLMTVFVLAC 

        70         80         90        100        110        120 
FIGFYVVWSV TPALHSPLMG VTNAISSVIV VGALIATGPE AFSASKVLGF FAILLASVNI 

       130 
FGGFIVTQRM LAMFKKKQK

P0C187 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools