PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
TISSUE=Venom;
DOI=10.1016/j.bbapap.2006.01.021; PubMed=16574513 [NCBI, ExPASy, EBI, Israel, Japan]
Samel M., Vija H., Ronnholm G., Siigur J., Kalkkinen N., Siigur E.;
"Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom.";
Biochim. Biophys. Acta 1764:707-714(2006).

Comments

FUNCTION: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids (the most specific substrate is L-Phe, followed by L-Met, L-Leu, L-Phe, L-Ile, L-Arg and L-His). Inhibits both ADP-induced platelet aggregation dose-dependently. Has an ability to induce apoptosis in cultured HeLa and K562 cells. May have an ability to induce hemorrhage. May have an antibacterial activity.
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Glycosylated (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

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Cross-references

3D structure databases
ModBase	P0C2D7.
Family and domain databases
BLOCKS	P0C2D7.
Phylogenomic databases
HOVERGEN	P0C2D7; -.
Other
ProtoNet	P0C2D7.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein; Oxidoreductase; Secreted; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >88`	`>88`	`L-amino-acid oxidase.`	`PRO_0000273573`
`NP_BIND`	`83 86`	`4`	`FAD (By similarity).`
`BINDING`	`74 74`		`FAD (By similarity).`
`NON_CONS`	`37 38`
`NON_CONS`	`44 45`
`NON_CONS`	`52 53`
`NON_CONS`	`61 62`
`NON_CONS`	`68 69`
`NON_TER`	`88 88`

Sequence information

Length: 88 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 10295 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: D2A63168391A7965 [This is a checksum on the sequence]

        10         20         30         40         50         60 
ADDKNPLEEC FREDDYEEFL EIAKNGLKKT SNPKHIVYPV KPSEQLYEES LRDQLPTSMH 

        70         80 
RYPSMIQKIF FAGEYTANAH GWIDSTIK

P0C2D7 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools