[1]	NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. DOI=10.1016/0378-1119(89)90224-2; PubMed=2777081 [NCBI, ExPASy, EBI, Israel, Japan] Rodokanaki A., Holmes R.K., Borras T.; "Zeta-crystallin, a novel protein from the guinea pig lens is related to alcohol dehydrogenases."; Gene 78:215-224(1989).
[2]	CHARACTERIZATION. TISSUE=Liver; PubMed=1420281 [NCBI, ExPASy, EBI, Israel, Japan] Rao P.V., Zigler J.S. Jr.; "Purification and characterization of zeta-crystallin/quinone reductase from guinea pig liver."; Biochim. Biophys. Acta 1117:315-320(1992).
[3]	CHARACTERIZATION. TISSUE=Liver; PubMed=1370456 [NCBI, ExPASy, EBI, Israel, Japan] Rao P.V., Krishna C.M., Zigler J.S. Jr.; "Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase."; J. Biol. Chem. 267:96-102(1992).

Comments

FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics.
CATALYTIC ACTIVITY: NADPH + quinone = NADP⁺ + semiquinone.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: In guinea pigs it constitutes about 10% of the water soluble proteins of the lens.
DISEASE: A genomic mutation causing the deletion of 34 amino acids was clearly associated with a hereditary nuclear cataract in a line of strain 13 guinea pigs.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M26936; AAA37035.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JS0230; CYGPZ.

3D structure databases

HSSP

P39462; 1JVB. [HSSP ENTRY / PDB]

SMR

P11415; 6-329.

ModBase

P11415.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002364; Quin_OxRdtase/zeta-crystal_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS01162; QOR_ZETA_CRYSTAL; 1.

BLOCKS

P11415.

Genome annotation databases

Ensembl

ENSCPOG00000006521; Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGEN

P11415; -.

Other

ProtoNet

P11415.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Direct protein sequencing; Eye lens protein; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 329`	`329`		`Quinone oxidoreductase.`	`PRO_0000160905`

Sequence information

Length: 329 AA [This is the length of the unprocessed precursor]

Molecular weight: 35202 Da [This is the MW of the unprocessed precursor]

CRC64: 1463632C672C234F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATGQKLMRA IRVFEFGGPE VLKVQSDVAV PIPKDHQVLI KVHACGINPV ETYIRSGTYT 

        70         80         90        100        110        120 
RIPLLPYTPG TDVAGVVESI GNDVSAFKKG DRVFTTSTIS GGYAEYALAS DHTVYRLPEK 

       130        140        150        160        170        180 
LDFRQGAAIG IPYFTACRAL FHSARAKAGE SVLVHGASGG VGLAACQIAR AYGLKVLGTA 

       190        200        210        220        230        240 
GTEEGQKVVL QNGAHEVFNH RDAHYIDEIK KSIGEKGVDV IIEMLANVNL SNDLKLLSCG 

       250        260        270        280        290        300 
GRVIIVGCRG SIEINPRDTM AKESTISGVS LFSSTKEEFQ QFASTIQAGM ELGWVKPVIG 

       310        320 
SQYPLEKASQ AHENIIHSSG TVGKTVLLM

P11415 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools