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UniProtKB/Swiss-Prot entry P12684


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH2_YEAST
Primary accession number P12684
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on October 1, 1989 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 87)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms HMG-CoA reductase 2
EC 1.1.1.34
Gene name
Name: HMG2
OrderedLocusNames: YLR450W
ORFNames: L9324.2
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3065625 [NCBI, ExPASy, EBI, Israel, Japan]
Basson M.E., Thorsness M., Finer-Moore J., Stroud R.M., Rine J.;
"Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.";
Mol. Cell. Biol. 8:3797-3808(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169871 [NCBI, ExPASy, EBI, Israel, Japan]
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 772-961.
PubMed=3526336 [NCBI, ExPASy, EBI, Israel, Japan]
Basson M.E., Thorsness M., Rine J.;
"Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase.";
Proc. Natl. Acad. Sci. U.S.A. 83:5563-5567(1986).
[4]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[5]
TOPOLOGY [LARGE SCALE ANALYSIS].
DOI=10.1073/pnas.0604075103; PubMed=16847258 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H., Melen K., Oesterberg M., von Heijne G.;
"A global topology map of the Saccharomyces cerevisiae membrane proteome.";
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-565, AND MASS SPECTROMETRY.
DOI=10.1021/pr060559j; PubMed=17330950 [NCBI, ExPASy, EBI, Israel, Japan]
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.;
"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.";
J. Proteome Res. 6:1190-1197(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-548; THR-565; THR-568 AND SER-655, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M700468-MCP200; PubMed=18407956 [NCBI, ExPASy, EBI, Israel, Japan]
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M22255; AAA34677.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U22382; AAB67527.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B30239; B30239.
RefSeq NP_013555.1; -.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase P12684.
Protein-protein interaction databases
DIP DIP:6277N; -.
IntAct P12684; -.
Enzyme and pathway databases
BioCyc MetaCyc:MON-650; -.
Organism-specific databases
CYGD YLR450w; -.
SGD S000004442; HMG2.
Yeast-GFP YLR450W.
Gene expression databases
ArrayExpress P12684; -.
GermOnline YLR450W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (traceable author statement from SGD).
GO:0005635; Cellular component: nuclear envelope (traceable author statement from SGD).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
IPR000731; SSD_5TM.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PS50156; SSD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P12684.
Genome annotation databases
Ensembl YLR450W; Saccharomyces cerevisiae. [Contig view]
GeneID 851171; -.
GenomeReviews Y13138_GR; YLR450W.
KEGG sce:YLR450W; -.
NMPDR fig|4932.3.peg.4586; -.
Phylogenomic databases
HOGENOM P12684; -.
Other
LinkHub P12684; -.
ProtoNet P12684.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid synthesis; Membrane; NADP; Oxidoreductase; Phosphoprotein; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1045  1045     3-hydroxy-3-methylglutaryl-coenzyme A reductase 2. PRO_0000114457
TOPO_DOM   1     26  26     Lumenal (Potential). 
TRANSMEM   27     53  27     Potential. 
TOPO_DOM   54    185  132     Cytoplasmic (Potential). 
TRANSMEM   186    210  25     Potential. 
TOPO_DOM   211    240  30     Lumenal (Potential). 
TRANSMEM   241    265  25     Potential. 
TOPO_DOM   266    298  33     Cytoplasmic (Potential). 
TRANSMEM   299    323  25     Potential. 
TOPO_DOM   324    330  7     Lumenal (Potential). 
TRANSMEM   331    356  26     Potential. 
TOPO_DOM   357    396  40     Cytoplasmic (Potential). 
TRANSMEM   397    421  25     Potential. 
TOPO_DOM   422    497  76     Lumenal (Potential). 
TRANSMEM   498    523  26     Potential. 
TOPO_DOM   524   1045  522     Cytoplasmic (Potential). 
REGION   524    613  90     Linker. 
REGION   614   1045  432     Catalytic. 
ACT_SITE   710    710        Charge relay system (By similarity). 
ACT_SITE   844    844        Charge relay system (By similarity). 
ACT_SITE   920    920        Charge relay system (By similarity). 
ACT_SITE   1016   1016        Proton donor (By similarity). 
MOD_RES   548    548        Phosphothreonine. 
MOD_RES   565    565        Phosphothreonine. 
MOD_RES   568    568        Phosphothreonine. 
MOD_RES   655    655        Phosphoserine. 
CARBOHYD   428    428        N-linked (GlcNAc...) (Potential). 
CARBOHYD   455    455        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1045 AA [This is the length of the unprocessed precursor] Molecular weight: 115692 Da [This is the MW of the unprocessed precursor] CRC64: 1FD9DCD3AC01B15E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLPLKTIVH LVKPFACTAR FSARYPIHVI VVAVLLSAAA YLSVTQSYLN EWKLDSNQYS 

        70         80         90        100        110        120 
TYLSIKPDEL FEKCTHYYRS PVSDTWKLLS SKEAADIYTP FHYYLSTISF QSKDNSTTLP 

       130        140        150        160        170        180 
SLDDVIYSVD HTRYLLSEEP KIPTELVSEN GTKWRLRNNS NFILDLHNIY RNMVKQFSNK 

       190        200        210        220        230        240 
TSEFDQFDLF IILAAYLTLF YTLCCLFNDM RKIGSKFWLS FSALSNSACA LYLSLYTTHS 

       250        260        270        280        290        300 
LLKKPASLLS LVIGLPFIVV IIGFKHKVRL AAFSLQKFHR ISIDKKITVS NIIYEAMFQE 

       310        320        330        340        350        360 
GAYLIRDYLF YISSFIGCAI YARHLPGLVN FCILSTFMLV FDLLLSATFY SAILSMKLEI 

       370        380        390        400        410        420 
NIIHRSTVIR QTLEEDGVVP TTADIIYKDE TASEPHFLRS NVAIILGKAS VIGLLLLINL 

       430        440        450        460        470        480 
YVFTDKLNAT ILNTVYFDST IYSLPNFINY KDIGNLSNQV IISVLPKQYY TPLKKYHQIE 

       490        500        510        520        530        540 
DSVLLIIDSV SNAIRDQFIS KLLFFAFAVS ISINVYLLNA AKIHTGYMNF QPQSNKIDDL 

       550        560        570        580        590        600 
VVQQKSATIE FSETRSMPAS SGLETPVTAK DIIISEEIQN NECVYALSSQ DEPIRPLSNL 

       610        620        630        640        650        660 
VELMEKEQLK NMNNTEVSNL VVNGKLPLYS LEKKLEDTTR AVLVRRKALS TLAESPILVS 

       670        680        690        700        710        720 
EKLPFRNYDY DRVFGACCEN VIGYMPIPVG VIGPLIIDGT SYHIPMATTE GCLVASAMRG 

       730        740        750        760        770        780 
CKAINAGGGA TTVLTKDGMT RGPVVRFPTL IRSGACKIWL DSEEGQNSIK KAFNSTSRFA 

       790        800        810        820        830        840 
RLQHIQTCLA GDLLFMRFRT TTGDAMGMNM ISKGVEYSLK QMVEEYGWED MEVVSVSGNY 

       850        860        870        880        890        900 
CTDKKPAAIN WIEGRGKSVV AEATIPGDVV KSVLKSDVSA LVELNISKNL VGSAMAGSVG 

       910        920        930        940        950        960 
GFNAHAANLV TALFLALGQD PAQNVESSNC ITLMKEVDGD LRISVSMPSI EVGTIGGGTV 

       970        980        990       1000       1010       1020 
LEPQGAMLDL LGVRGPHPTE PGANARQLAR IIACAVLAGE LSLCSALAAG HLVQSHMTHN 

      1030       1040 
RKTNKANELP QPSNKGPPCK TSALL 

P12684 in FASTA format

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View entry in raw text format (no links)
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