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UniProtKB/Swiss-Prot entry P12762

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDH2_HORSE
Primary accession number P12762
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on October 1, 1989 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 58)
Name and origin of the protein
Protein name Aldehyde dehydrogenase, mitochondrial
Synonyms EC 1.2.1.3
ALDH class 2
ALDHI
ALDH-E2
Gene name
Name: ALDH2
From
Equus caballus (Horse) [TaxID: 9796] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE.
PubMed=3350012 [NCBI, ExPASy, EBI, Israel, Japan]
Johansson J., von Bahr-Lindstroem H., Jeck R., Woenckhaus C., Joernvall H.;
"Mitochondrial aldehyde dehydrogenase from horse liver. Correlations of the same species variants for both the cytosolic and the mitochondrial forms of an enzyme.";
Eur. J. Biochem. 172:527-533(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
PIR S00364; S00364.
3D structure databases
HSSP P05091; 1O01. [HSSP ENTRY / PDB]
SMR P12762; 7-500.
ModBase P12762.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P12762.
Phylogenomic databases
HOVERGEN P12762; -.
Other
ProtoNet P12762.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   500  500     Aldehyde dehydrogenase, mitochondrial. PRO_0000056467
NP_BIND   245   250  6     NAD (By similarity). 
ACT_SITE   268   268        Proton acceptor (By similarity). 
ACT_SITE   302   302        Nucleophile (By similarity). 
SITE   169   169  1     Transition state stabilizer (By similarity). 
VARIANT   1     1  1     A -> L. 
VARIANT   1     1  1     A -> S. 
Sequence information
Length: 500 AA [This is the length of the unprocessed precursor] Molecular weight: 54166 Da [This is the MW of the unprocessed precursor] CRC64: 7F95364A73383B24 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
AAAATQAVPA PNQQPEVFYN QIFINNEWHD AVSKKTFPTV NPSTGEVICQ VAAGDKEDVD 

        70         80         90        100        110        120 
RAVKAARAAF QLGSPWRRMD ASDRGRLLNR LADLIERDRT YLAALETLDN GKPYVISYLV 

       130        140        150        160        170        180 
DLDMVLKCLR YYAGWADKYH GKTIPIDGDF FSYTRHEPVG VCGQIIPWNF PLLMQAAKLG 

       190        200        210        220        230        240 
PALATGNVVV MKVAEQTPLT ALYVANLTKE AGFPPGVVNV VPGFGPTAGA AIASHEDVDK 

       250        260        270        280        290        300 
VAFTGSTEVG HLIQVAAGRS NLKKVTLELG GKSPNIIVSD ADMDWAVEQA HFALFFNQGQ 

       310        320        330        340        350        360 
CCGAGSRTFV QEDVYAEFVE RSVARAKSRV VGNPFDSQTE QGPQVDETQF NKVLGYIKSG 

       370        380        390        400        410        420 
KEEGAKLLCG GGAAADRGYF IQPTVFGDVQ DGMTIAKEEI FGPVMQILKF KTIEEVVGRA 

       430        440        450        460        470        480 
NNSKYGLAAA VFTKDLDKAN YLSQALQAGT VWINCYDVFG AQSPFGGYKM SGNGRELGEY 

       490        500 
GLQAYTEVKT VTIKVPQKNS
P12762 in FASTA format

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