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UniProtKB/Swiss-Prot entry P14650

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PERT_RAT
Primary accession number P14650
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on April 1, 1990 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 89)
Name and origin of the protein
Protein name Thyroid peroxidase [Precursor]
Synonyms TPO
EC 1.11.1.8
Gene name
Name: Tpo
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/17.20.8380; PubMed=2813071 [NCBI, ExPASy, EBI, Israel, Japan]
Derwahl M., Seto P., Rapoport B.;
"Complete nucleotide sequence of the cDNA for thyroid peroxidase in FRTL5 rat thyroid cells.";
Nucleic Acids Res. 17:8380-8380(1989).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 145-914.
PubMed=2691880 [NCBI, ExPASy, EBI, Israel, Japan]
Isozaki O., Kohn L.D., Kozak C.A., Kimura S.;
"Thyroid peroxidase: rat cDNA sequence, chromosomal localization in mouse, and regulation of gene expression by comparison to thyroglobulin in rat FRTL-5 cells.";
Mol. Endocrinol. 3:1681-1692(1989).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X17396; CAA35257.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M31655; AAA42265.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S07047; S07047.
RefSeq NP_062226.1; -.
UniGene Rn.91199
3D structure databases
HSSP P05164; 1D5L. [HSSP ENTRY / PDB]
ModBase P14650.
Protein family/group databases
PeroxiBase 3973; RnoTPO.
Organism-specific databases
RGD 3900; Tpo.
Gene expression databases
ArrayExpress P14650; -.
GermOnline ENSRNOG00000004646; Rattus norvegicus.
Ontologies
GO
GO:0004447; Molecular function: iodide peroxidase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR016060; Complement_control_module.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR013091; EGF_Ca_bd_2.
IPR013032; EGF_like_reg_CS.
IPR002007; Haem_peroxidase_animal.
IPR002016; Haem_peroxidase_pln/fun/bac.
IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.
Gene3D G3DSA:2.10.70.10; Complement_control_module; 1.
G3DSA:1.10.640.10; Haem_peroxidase_animal; 1.
Pfam PF03098; An_peroxidase; 1.
PF07645; EGF_CA; 1.
PF00084; Sushi; 1.
Pfam graphical view of domain structure.
PRINTS PR00457; ANPEROXIDASE.
SMART SM00032; CCP; 1.
SM00179; EGF_CA; 1.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 1.
PS00022; EGF_1; FALSE_NEG.
PS01186; EGF_2; 1.
PS50026; EGF_3; 1.
PS01187; EGF_CA; 1.
PS00435; PEROXIDASE_1; 1.
PS00436; PEROXIDASE_2; FALSE_NEG.
PS50292; PEROXIDASE_3; 1.
PS50923; SUSHI; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P14650.
Genome annotation databases
Ensembl ENSRNOG00000004646; Rattus norvegicus. [Contig view]
GeneID 54314; -.
KEGG rno:54314; -.
Phylogenomic databases
HOVERGEN P14650; -.
Other
ProtoNet P14650.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; EGF-like domain; Glycoprotein; Heme; Hydrogen peroxide; Iron; Membrane; Metal-binding; Oxidoreductase; Peroxidase; Signal; Sushi; Thyroid hormones biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    31  31     Potential. 
CHAIN   32   914  883     Thyroid peroxidase. PRO_0000023665
TOPO_DOM   32   834  803     Extracellular (Potential). 
TRANSMEM   835   859  25     Potential. 
TOPO_DOM   860   914  55     Cytoplasmic (Potential). 
DOMAIN   728   783  56     Sushi. 
DOMAIN   784   827  44     EGF-like; calcium-binding (Potential). 
ACT_SITE   233   233        Proton acceptor (By similarity). 
METAL   234   234        Calcium (By similarity). 
METAL   313   313        Calcium (By similarity). 
METAL   315   315        Calcium (via carbonyl oxygen) (By similarity). 
METAL   317   317        Calcium (By similarity). 
METAL   319   319        Calcium (By similarity). 
METAL   482   482        Iron (heme axial ligand) (By similarity). 
BINDING   232   232        Heme (covalent; via 2 links) (By similarity). 
BINDING   387   387        Heme (covalent; via 2 links) (By similarity). 
SITE   384   384  1     Transition state stabilizer (By similarity). 
CARBOHYD   123   123        N-linked (GlcNAc...) (Potential). 
CARBOHYD   271   271        N-linked (GlcNAc...) (Potential). 
CARBOHYD   299   299        N-linked (GlcNAc...) (Potential). 
CARBOHYD   334   334        N-linked (GlcNAc...) (Potential). 
CARBOHYD   603   603        N-linked (GlcNAc...) (Potential). 
DISULFID   136   152        By similarity. 
DISULFID   253   263        By similarity. 
DISULFID   257   278        By similarity. 
DISULFID   586   643        By similarity. 
DISULFID   684   709        By similarity. 
DISULFID   730   770        By similarity. 
DISULFID   756   782        By similarity. 
DISULFID   788   802        By similarity. 
DISULFID   796   811        By similarity. 
DISULFID   813   826        By similarity. 
CONFLICT   194   195        FP -> LG (in Ref. 2; AAA42265). 
CONFLICT   198   198        P -> S (in Ref. 2; AAA42265). 
CONFLICT   228   228        G -> A (in Ref. 2; AAA42265). 
CONFLICT   592   594        DTG -> ETP (in Ref. 2; AAA42265). 
Sequence information
Length: 914 AA [This is the length of the unprocessed precursor] Molecular weight: 101460 Da [This is the MW of the unprocessed precursor] CRC64: B700B89439E85191 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRTLGAMAVM LVVMGTAIFL PFLLRSRDIL GGKTMTSHVI SVVETSQLLV DNAVYNTMKR 

        70         80         90        100        110        120 
NLKKRGVLSP AQLLSFSKLP ESTSGAISRA AEIMETSIQV MKREQSQFST DALSADILAT 

       130        140        150        160        170        180 
IANLSGCLPF MLPPRCPDTC LANKYRPITG VCNNRDHPRW GASNTALARW LPPVYEDGFS 

       190        200        210        220        230        240 
QPRGWNPNFL YHGFPLPPVR EVTRHLIQVS NEAVTEDDQY SDFLPVWGQY IDHDIALTPQ 

       250        260        270        280        290        300 
STSTAAFWGG VDCQLTCENQ NPCFPIQLPS NSSRTTACLP FYRSSAACGT GDQGALFGNL 

       310        320        330        340        350        360 
SAANPRQQMN GLTSFLDAST VYGSSPGVEK QLRNWSSSAG LLRVNTLHLD SGRAYLPFAS 

       370        380        390        400        410        420 
AACAPEPGAP HANRTPCFLA GDGRASEVPA LAAVHTLWLR EHNRLATAFK AINTHWSANT 

       430        440        450        460        470        480 
AYQEARKVVG ALHQIITMRD YIPKILGPDA FRQYVGPYEG YNPTVNPTVS NVFSTAAFRF 

       490        500        510        520        530        540 
GHATVHPLVR RLNTDFQDHT ELPRLQLHDV FFRPWRLIQE GGLDPIVRGL LARPAKLQVQ 

       550        560        570        580        590        600 
EQLMNEELTE RLFVLSNVGT LDLASLNLQR GRDHGLPGYN EWREFCGLSR LDTGAELNKA 

       610        620        630        640        650        660 
IANRSMVNKI MELYKHADNI DVWLGGLAEK FLPGARTGPL FACIIGKQMK ALRDGDRFWW 

       670        680        690        700        710        720 
ENSHVFTDAQ RQELEKHSLP RVICDNTGLT RVPVDAFRIG KFPQDFESCE EIPSMDLRLW 

       730        740        750        760        770        780 
RETFPQDDKC VFPEKVDNGN FVHCEESGKL VLVYSCFHGY KLQGQEQVTC TQNGWDSEPP 

       790        800        810        820        830        840 
VCKDVNECAD LTHPPCHSSA KCKNTKGSFQ CVCTDPYMLG EDEKTCIDSG RLPRASWVSI 

       850        860        870        880        890        900 
ALGALLIGGL ASLSWTVICR WTHADKKSTL LITERVTMES GFRKSQESGI SPQKAEVQDA 

       910 
EQEPAYGSRV LLCE
P14650 in FASTA format

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