[1]	PROTEIN SEQUENCE. PubMed=6723662 [NCBI, ExPASy, EBI, Israel, Japan] von Bahr-Lindstroem H., Hempel J., Joernvall H.; "The cytoplasmic isoenzyme of horse liver aldehyde dehydrogenase. Relationship to the corresponding human isoenzyme."; Eur. J. Biochem. 141:37-42(1984).

Comments

FUNCTION: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
CATALYTIC ACTIVITY: Retinal + NAD⁺ + H₂O = retinoate + NADH.
PATHWAY: Cofactor metabolism; retinol metabolism .
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: The N-terminus is blocked.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	S02302; S02302.
3D structure databases
HSSP	P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase	P15437.
Family and domain databases
InterPro	IPR016160; Ald_DHase_CS. IPR016162; Ald_DHase_N. IPR015590; Aldehyde_DHase. Graphical view of domain structure.
Gene3D	G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER	PTHR11699; Aldehyde_dehyd; 1.
Pfam	PF00171; Aldedh; 1. Pfam graphical view of domain structure.
PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1. PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS	P15437.
Phylogenomic databases
HOVERGEN	P15437; -.
Other
ProtoNet	P15437.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 500`	`500`	`Retinal dehydrogenase 1.`	`PRO_0000056414`
`NP_BIND`	`245 250`	`6`	`NAD (By similarity).`
`ACT_SITE`	`268 268`		`Proton acceptor (By similarity).`
`ACT_SITE`	`302 302`		`Nucleophile (By similarity).`
`SITE`	`169 169`	`1`	`Transition state stabilizer (By similarity).`
`MOD_RES`	`1 1`		`N-acetylserine (Probable).`

Sequence information

Length: 500 AA [This is the length of the unprocessed precursor]

Molecular weight: 54744 Da [This is the MW of the unprocessed precursor]

CRC64: A438E4204BEF7340 [This is a checksum on the sequence]

        10         20         30         40         50         60 
SSSGTPDLPV LLTDLKFQYT KIFINNEWHD SVSGKKFPVF NPATEEKLCE VEEGDKEDVN 

        70         80         90        100        110        120 
KAVAAARQAF QIGSPWRTMD ASERGRLLYK LADLVERDRL ILATMESMNG GKLFSNAYLM 

       130        140        150        160        170        180 
DLGGCLKTLR YCAGWADKIQ GRTIPSDGNF FTYTRHEPVG VCGQILPWNF PLLMFLWKIA 

       190        200        210        220        230        240 
PALSCGNTVV VKPAEQTPLS ALHVATLIKE AGFPPGVVNI VPGYGPTAGA AISSHMDIDK 

       250        260        270        280        290        300 
VAFTGSTEVG KLIKEAAGKS NLKRVTLELG GKSPFIVFAD ADLETALEVT HQALFYHQGQ 

       310        320        330        340        350        360 
CCVAASRLFV EESIYDEFVR RSVERAKKYV LGNPLTPGVS QGPQIDKEQY DKILDLIESG 

       370        380        390        400        410        420 
KKEGAKLECG GGPWGNKGYF IQPTVFSNVS DEMRIAKEEI FGPVQQIMKF KSLDDVIKRA 

       430        440        450        460        470        480 
NNTTYGLFAG SFTKDLDKAI TVSAALQAGT VWVNCYGVVS AQCPFGGFKM SGNGREMGEY 

       490        500 
GFHEYTEVKT VTVKISQKNS

P15437 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools