[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Stock 51; DOI=10.1093/nar/18.1.173; PubMed=2308823 [NCBI, ExPASy, EBI, Israel, Japan] Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E., Cummings D.J.; "Nucleotide sequence of the mitochondrial genome of Paramecium."; Nucleic Acids Res. 18:173-180(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0378-1119(89)90320-X; PubMed=2670676 [NCBI, ExPASy, EBI, Israel, Japan] Pritchard A.E., Venuti S.E., Ghalambor M.A., Sable C.L., Cummings D.J.; "An unusual region of Paramecium mitochondrial DNA containing chloroplast-like genes."; Gene 78:121-134(1989).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X15917; CAA34042.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M26930; AAA79254.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S07733; S07733.

3D structure databases

ModBase

P15689.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

PROSITE

PS00535; COMPLEX1_49K; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 400`	`400`		`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118590`

Sequence information

Length: 400 AA [This is the length of the unprocessed precursor]

Molecular weight: 46077 Da [This is the MW of the unprocessed precursor]

CRC64: 1E66944DF516D4F7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKAICVNFGP QHPAAHGVLR LILQLNGEVV EKMDIHIGLL HRGSEKLMET KPYLQSMPYF 

        70         80         90        100        110        120 
DRLDYVSMMV QEHAYCLAIE ALLNTTNYTA NFVLVRTMFD ELTRILNHML AIACHALDIG 

       130        140        150        160        170        180 
SMSSIFWAFE EREKIMEFYE RVCGRRMHAA FYRPNEVNLN FLSVKLLTDI LEFNNNCLTT 

       190        200        210        220        230        240 
LSEMHNILTY NKIWKQRLVN IGSISYKDCL DFGLTGVMAR STGIKRDLRM DAFDTYANYY 

       250        260        270        280        290        300 
YLNFRSYTGQ AGDSYDRFLI RMNEMSESIN IISQAIFKLT TSKNTCSPAS ILKALNKKKF 

       310        320        330        340        350        360 
ISQTYKNEYS SMEKLITHFK YWSEGFKIQS NWTYQAVESP KGEFGVTLVS DGSNKPYRCK 

       370        380        390        400 
VRSPAYHHLQ VLPKMSKGHL LADLSALIGT IDIVFGEIDR

P15689 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools