[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=cv. R6-67; TISSUE=Scutellum; DOI=10.1016/0167-4781(88)90030-9; PubMed=2461221 [NCBI, ExPASy, EBI, Israel, Japan] Redinbaugh M.G., Wadsworth G.J., Scandalios J.G.; "Characterization of catalase transcripts and their differential expression in maize."; Biochim. Biophys. Acta 951:104-116(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=cv. Wisconsin 64A; TISSUE=Leaf; PubMed=8220459 [NCBI, ExPASy, EBI, Israel, Japan] Guan L., Scandalios J.G.; "Characterization of the catalase antioxidant defense gene Cat1 of maize, and its developmentally regulated expression in transgenic tobacco."; Plant J. 3:527-536(1993).

Comments

FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Peroxisome.
TISSUE SPECIFICITY: Scutella, milky endosperm of immature kernels, leaves and epicotyls.
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X12538; CAA31056.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60135; CAA42720.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S48124; S48124.

NP_001105415.1; -.

3D structure databases

HSSP

P46206; 1M7S. [HSSP ENTRY / PDB]

ModBase

P18122.

Organism-specific databases

Gramene

P18122; -.

MaizeGDB

13855; -.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.

BLOCKS

P18122.

Genome annotation databases

GeneID

542369; -.

Other

ProtoNet

P18122.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Peroxisome.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 492`	`492`	`Catalase isozyme 1.`	`PRO_0000084946`
`ACT_SITE`	`65 65`		`By similarity.`
`ACT_SITE`	`138 138`		`By similarity.`
`METAL`	`348 348`		`Iron (heme axial ligand) (By similarity).`
`VARIANT`	`157 157`	`1`	`A -> V (in strain: cv. W64A).`
`VARIANT`	`211 211`	`1`	`S -> T (in strain: cv. W64A).`
`VARIANT`	`329 329`	`1`	`S -> I (in strain: cv. W64A).`
`VARIANT`	`483 483`	`1`	`P -> A (in strain: cv. W64A).`
`CONFLICT`	`332 332`		`A -> G (in Ref. 1; CAA31056/CAA42720).`
`CONFLICT`	`415 415`		`R -> G (in Ref. 1; CAA31056/CAA42720).`
`CONFLICT`	`456 456`		`H -> D (in Ref. 1; CAA31056/CAA42720).`

Sequence information

Length: 492 AA [This is the length of the unprocessed precursor]

Molecular weight: 56877 Da [This is the MW of the unprocessed precursor]

CRC64: CE10C93BEC1D9529 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDPYKHRPSS GSNSSFWTTN SGAPVWNNNS ALTVGQRGPI LLEDYHLIEK LAQFDRERIP 

        70         80         90        100        110        120 
ERVVHARGAS AKGFFEVTHD VSHLTCADFL RAPGVQTPVI VRFSTVVHER GSPETLRDPR 

       130        140        150        160        170        180 
GFAVKFYTRE GNFDLVGNNM PVFFIRDGMK FPDMVHAFKP NPKTNLQENW RIVDFFSHHP 

       190        200        210        220        230        240 
ESLHMFTFLF DDVGIPLNYR HMEGFGVNTY SLINRDGKPH LVKFHWKPTC GVKCLLDNEA 

       250        260        270        280        290        300 
VTVGGTCHSH ATKDLYDSIA AGNYPEWKLY IQTIDLDHED KFDFDPLDVT KTWPEDIIPL 

       310        320        330        340        350        360 
QPVGRMVLNK NVDNFFAENE QIAFCPAISV PAIHYSDDKL LQTRIFSYAD TQRHRLGPNY 

       370        380        390        400        410        420 
LMLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRFDPA RHAEKVPIPP RVLTRCREKC 

       430        440        450        460        470        480 
IIQKENNFKQ AGERYRSFDP ARQDRFIQRW VDALTHPRVT HEHRTIWISY WSQCDAALGQ 

       490 
KLPSRLNLKP SM

P18122 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools