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UniProtKB/Swiss-Prot entry P18405


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name S5A1_HUMAN
Primary accession number P18405
Secondary accession numbers Q9UHY4 Q9UP36 Q9UP37
Integrated into Swiss-Prot on November 1, 1990
Sequence was last modified on November 1, 1990 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 84)
Name and origin of the protein
Protein name 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms EC 1.3.99.5
Steroid 5-alpha-reductase 1
S5AR
SR type 1
Gene name
Name: SRD5A1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2339109 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S., Russell D.W.;
"Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.";
Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0888-7543(91)90038-G; PubMed=1686016 [NCBI, ExPASy, EBI, Israel, Japan]
Jenkins E.P., Hsieh C.L., Milatovich A., Normington K., Berman D.M., Francke U., Russell D.W.;
"Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue.";
Genomics 11:1102-1112(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Yu W., Sarginson J., Gibbs R.A.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal gland;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Rieder M.J., Livingston R.J., Daniels M.R., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 155-187.
DOI=10.1007/s004240100019; PubMed=11678334 [NCBI, ExPASy, EBI, Israel, Japan]
Eminovic I., Liovic M., Prezelj J., Kocijancic A., Rozman D., Komel R.;
"New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8.";
Pflugers Arch. 442:R187-R189(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M32313; AAA35490.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68886; AAA60995.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68882; AAA60995.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68883; AAA60995.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68884; AAA60995.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68885; AAA60995.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF052126; AAC28620.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF113128; AAF14869.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006834; AAP35480.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY341029; AAP88935.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007033; AAH07033.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008673; AAH08673.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF073301; AAC26862.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF073302; AAC26863.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF073303; AAC26864.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF073304; AAC26865.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A55274; A55274.
RefSeq NP_001038.1; -.
UniGene Hs.552
3D structure databases
ModBase P18405.
Polymorphism databases
NIEHS-SNPs SRD5A1.
Organism-specific databases
H-InvDB HIX0004734; -.
HGNC HGNC:11284; SRD5A1.
GenAtlas SRD5A1.
MIM 184753; gene. [NCBI / EBI]
PharmGKB PA36112; -.
GeneCards P18405.
Gene expression databases
ArrayExpress P18405; -.
CleanEx HS_SRD5A1; -.
GermOnline ENSG00000145545; Homo sapiens.
Ontologies
GO
GO:0009055; Molecular function: electron carrier activity (traceable author statement from UniProtKB).
GO:0007530; Biological process: sex determination (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016636; 3-oxo-5-alpha-steroid_4-DH.
IPR001104; 3-oxo-5_a-steroid_4-DHase_C.
Graphical view of domain structure.
Pfam PF02544; Steroid_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF015596; 5_alpha-SR2; 1.
PROSITE PS50244; S5A_REDUCTASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P18405.
Genome annotation databases
Ensembl ENSG00000145545; Homo sapiens. [Contig view]
GeneID 6715; -.
KEGG hsa:6715; -.
Phylogenomic databases
HOGENOM P18405; -.
HOVERGEN P18405; -.
Other
DrugBank DB01126; Dutasteride.
DB01216; Finasteride.
LinkHub P18405; -.
SOURCE SRD5A1; Homo sapiens.
ProtoNet P18405.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Differentiation; Endoplasmic reticulum; Membrane; Microsome; Oxidoreductase; Sexual differentiation; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   259  259     3-oxo-5-alpha-steroid 4-dehydrogenase 1. PRO_0000213674
TRANSMEM   12    29  18     Potential. 
TRANSMEM   86   106  21     Potential. 
TRANSMEM   111   131  21     Potential. 
TRANSMEM   151   171  21     Potential. 
TRANSMEM   209   229  21     Potential. 
CONFLICT   29    76        Missing (in Ref. 4; AAF14869). 
Sequence information
Length: 259 AA [This is the length of the unprocessed precursor] Molecular weight: 29459 Da [This is the MW of the unprocessed precursor] CRC64: AEF9FD5521E43AC4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE 

        70         80         90        100        110        120 
LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA 

       130        140        150        160        170        180 
IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD 

       190        200        210        220        230        240 
TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY 

       250 
LRKFEEYPKF RKIIIPFLF 

P18405 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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