NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sp6;
DOI=10.1007/BF00334360; PubMed=2664449 [NCBI, ExPASy, EBI, Israel, Japan]
Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M.;
"Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
Mol. Gen. Genet. 216:224-229(1989).

Comments

FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity).
CATALYTIC ACTIVITY: L-histidinol + 2 NAD⁺ = L-histidine + 2 NADH.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 .
SIMILARITY: Belongs to the histidinol dehydrogenase family.
CAUTION: Highly divergent compared to other bacterial hisD.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X17435; CAA35477.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

PE0006; PE0006.

3D structure databases

ModBase

P18786.

Ontologies

GO:0004399;	Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105;	Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01024; atypical; 1.
PBIL [Tree]

InterPro

IPR001692; Histidinol_DHase.
Graphical view of domain structure.

PROSITE

PS00611; HISOL_DEHYDROGENASE; PARTIAL.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Histidine biosynthesis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 128`	`>128`	`Putative histidinol dehydrogenase.`	`PRO_0000135719`
`NON_TER`	`1 1`

Sequence information

Length: 128 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 14111 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: BDF52031D2B04CCD [This is a checksum on the sequence]

        10         20         30         40         50         60 
ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA GDGWGFAGLR 

        70         80         90        100        110        120 
QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT MHTHALSGIA TDGHRRFRRR 


HLCRPRAS

P18786 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools