NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/BF00330572; PubMed=2550758 [NCBI, ExPASy, EBI, Israel, Japan]
Hawkins A.R., Gurr S.J., Montague P., Kinghorn J.R.;
"Nucleotide sequence and regulation of expression of the Aspergillus nidulans gdhA gene encoding NADP dependent glutamate dehydrogenase.";
Mol. Gen. Genet. 218:105-111(1989).

Comments

CATALYTIC ACTIVITY: L-glutamate + H₂O + NADP⁺ = 2-oxoglutarate + NH₃ + NADPH.
SUBUNIT: Homohexamer.
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X16121; CAA34252.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S04904; S04904.

3D structure databases

HSSP

P24295; 1AUP. [HSSP ENTRY / PDB]

ModBase

P18819.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11606:SF2; GLFV_DH; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000185; Glu_DH; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 459`	`459`	`NADP-specific glutamate dehydrogenase.`	`PRO_0000182785`
`ACT_SITE`	`114 114`		`By similarity.`

Sequence information

Length: 459 AA [This is the length of the unprocessed precursor]

Molecular weight: 49608 Da [This is the MW of the unprocessed precursor]

CRC64: 682964399C002B7D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSNLPVEPEF EQAYKELAST LENSTLFEQH PEYRRALQVV SVPERVIQFR VVWENDKGEV 

        70         80         90        100        110        120 
QINRGYRVQF NSALGPYKGG LRFHPSVNLS ILKFLGFEQI FKNALTGLNM GGGKGGSDFD 

       130        140        150        160        170        180 
PKGKSDSEIR RFCTAFMTEL CKHIGADTDV PAGDIGVTGR EVGFLFGQYR RIRNQWEGVL 

       190        200        210        220        230        240 
TGKGGSWGGS LIRPEATGYG VVYYVQHMIK HVTGGKESFA GKRVAISGSG NVAQYAALKV 

       250        260        270        280        290        300 
IELGGSVVSL SDSKGSLIVK DESASFTPEE IALIADLKVA RKQLSELATS SAFAGKFTYI 

       310        320        330        340        350        360 
PDARPWTNIP GKFEVALPSA TQNEVSGEEA EHLIKSGVRY IAEGSNMGCT QAAIDIFEAH 

       370        380        390        400        410        420 
RNANPGDAIW YAPGKAANAG GVAVSGLEMA QNSARLSWTS EEVDARLKGI MEDCFKNGLE 

       430        440        450 
TAQKFATPAK GVLPSLVTGS NIAGFTKVAE AMKDQGDWW

P18819 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools