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UniProtKB/Swiss-Prot entry P19314

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P_METBR
Primary accession number P19314
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1990
Sequence was last modified on February 1, 1996 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase
Synonyms GAPDH
EC 1.2.1.59
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene name
Name: gap
From
Methanobacterium bryantii [TaxID: 2161] 
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DSM 862;
PubMed=2492940 [NCBI, ExPASy, EBI, Israel, Japan]
Fabry S., Lang J., Niermann T., Vingron M., Hensel R.;
"Nucleotide sequence of the glyceraldehyde-3-phosphate dehydrogenase gene from the mesophilic methanogenic archaebacteria Methanobacterium bryantii and Methanobacterium formicicum. Comparison with the respective gene structure of the closely related extreme thermophile Methanothermus fervidus.";
Eur. J. Biochem. 179:405-413(1989).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X14631; CAA32780.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S02804; S02804.
3D structure databases
HSSP P10618; 1CF2. [HSSP ENTRY / PDB]
SMR P19314; 1-338.
ModBase P19314.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0043891; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity (inferred from electronic annotation from EC).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00559; -; 1.
PBIL [Tree]
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006436; Glyceraldehyde-3-P_DHase_2_arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
ProDom PD007761; GAPDH_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01546; GAPDH-II_archae; 1.
PROSITE PS00071; GAPDH; 1.
BLOCKS P19314.
Other
ProtoNet P19314.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   338  338     Glyceraldehyde-3-phosphate dehydrogenase. PRO_0000145720
NP_BIND   11    12  2     NAD (By similarity). 
REGION   140   142  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   195   196  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   141   141        Nucleophile (By similarity). 
BINDING   111   111        NAD; via amide nitrogen (By similarity). 
BINDING   169   169        NAD (By similarity). 
BINDING   302   302        NAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 338 AA [This is the length of the unprocessed precursor] Molecular weight: 37013 Da [This is the MW of the unprocessed precursor] CRC64: 6E8B7529688D63A5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKSVGINGYG TIGKRVADAV SAQDDMKIVG VTKRSPDFEA RMAVENGYDL YISVPERESS 

        70         80         90        100        110        120 
FEEAGIKVTG TADELLEKLD IVVDCTPEGI GAKNKEGTYE KMGLKAIFQG GEKHDQIGLS 

       130        140        150        160        170        180 
FNSFSNYNDV IGKDYARVVS CNTTGLCRTL NPINDLCGIK KVRAVMVRRG ADPGQVKKGP 

       190        200        210        220        230        240 
INAIVPNPPT VPSHHGPDVQ TVMYDLNITT MALLVPTTLM HQHNLMVELE SSVSVDDIKE 

       250        260        270        280        290        300 
KLNETPRVLL LKAGEGLTST AGFMEYAKDL GRSRNDLFEI GVWEESLNIV DGELYYMQAI 

       310        320        330 
HQESDVVPEN VDAIRAMLEM ENDPSKSIQK TNKAMGIL
P19314 in FASTA format

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