[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1073/pnas.86.6.1963; PubMed=2784565 [NCBI, ExPASy, EBI, Israel, Japan] Kwon B.S., Weissman S.M.; "cDNA sequences of two inducible T-cell genes."; Proc. Natl. Acad. Sci. U.S.A. 86:1963-1967(1989).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BALB/c; PubMed=8133039 [NCBI, ExPASy, EBI, Israel, Japan] Kwon B.S., Kozak C.A., Kim K.K., Pickard R.T.; "Genomic organization and chromosomal localization of the T-cell antigen 4-1BB."; J. Immunol. 152:2256-2262(1994).
[3]	CHARACTERIZATION, AND PROTEIN SEQUENCE OF 24-29. PubMed=7678621 [NCBI, ExPASy, EBI, Israel, Japan] Pollok K.E., Kim Y.-J., Zhou Z., Hurtado J., Kin K.K., Pickard R.T., Kwon B.S.; "Inducible T cell antigen 4-1BB. Analysis of expression and function."; J. Immunol. 150:771-781(1993).

Comments

FUNCTION: Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation.
SUBUNIT: Principally an homodimer, but also found as a monomer. Associates with p56-LCK. Interacts with TRAF1, TRAF2 and TRAF3 (By similarity).
INTERACTION:
Q12933:TRAF2 (xeno); NbExp=1; IntAct=EBI-520693, EBI-355744;
P39429:Traf2; NbExp=2; IntAct=EBI-520693, EBI-520016;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on the surface of activated T-cells.
INDUCTION: Optimal by PMA and ionomycin.
SIMILARITY: Contains 4 TNFR-Cys repeats.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J04492; AAA40167.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U02567; AAA93113.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00118019; -.

PIR

B32393; B32393.

RefSeq

NP_001070977.1; -.
NP_035742.1; -.

UniGene

Mm.244187

3D structure databases

PDB

1D0J; X-ray; 2.50 A; G/H/I/J/K=231-236.

[ExPASy / RCSB / EBI]

PDBsum

1D0J; -.

ModBase

P20334.

Protein-protein interaction databases

DIP

DIP:1154N; -.

IntAct

P20334; 4.

Organism-specific databases

MGI

MGI:1101059; Tnfrsf9.

Gene expression databases

ArrayExpress

P20334; -.

Bgee

P20334; -.

GermOnline

ENSMUSG00000028965; Mus musculus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004872;	Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001368; TNFR_Cys_rich_reg.
Graphical view of domain structure.

Pfam

PF00020; TNFR_c6; 1.
Pfam graphical view of domain structure.

SMART

SM00208; TNFR; 2.
SMART graphical view of domain structure.

PROSITE

PS00652; TNFR_NGFR_1; 1.
PS50050; TNFR_NGFR_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000028965; Mus musculus. [Contig view]

GeneID

21942; -.

Phylogenomic databases

HOGENOM

P20334; -.

HOVERGEN

P20334; -.

OMA

P20334; CKQGQEL.

Other

NextBio

301576; -.

SOURCE

Tnfrsf9; Mus musculus.

ProtoNet

P20334.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Receptor; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`
`CHAIN`	`24 256`	`233`	`Tumor necrosis factor receptor superfamily member 9.`	`PRO_0000034578`
`TOPO_DOM`	`24 187`	`164`	`Extracellular (Potential).`
`TRANSMEM`	`188 208`	`21`	`Potential.`
`TOPO_DOM`	`209 256`	`48`	`Cytoplasmic (Potential).`
`REPEAT`	`24 45`	`22`	`TNFR-Cys 1.`
`REPEAT`	`46 85`	`40`	`TNFR-Cys 2.`
`REPEAT`	`86 117`	`32`	`TNFR-Cys 3.`
`REPEAT`	`118 159`	`42`	`TNFR-Cys 4.`
`CARBOHYD`	`128 128`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`138 138`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`28 37`		`By similarity.`
`DISULFID`	`31 44`		`By similarity.`
`DISULFID`	`47 61`		`By similarity.`
`DISULFID`	`64 77`		`By similarity.`
`DISULFID`	`67 85`		`By similarity.`
`DISULFID`	`87 93`		`By similarity.`
`DISULFID`	`98 105`		`By similarity.`
`DISULFID`	`101 116`		`By similarity.`
`DISULFID`	`119 133`		`By similarity.`
`DISULFID`	`139 158`		`By similarity.`

Sequence information

Length: 256 AA [This is the length of the unprocessed precursor]

Molecular weight: 27598 Da [This is the MW of the unprocessed precursor]

CRC64: 93A10D03C60813C4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGNNCYNVVV IVLLLVGCEK VGAVQNSCDN CQPGTFCRKY NPVCKSCPPS TFSSIGGQPN 

        70         80         90        100        110        120 
CNICRVCAGY FRFKKFCSST HNAECECIEG FHCLGPQCTR CEKDCRPGQE LTKQGCKTCS 

       130        140        150        160        170        180 
LGTFNDQNGT GVCRPWTNCS LDGRSVLKTG TTEKDVVCGP PVVSFSPSTT ISVTPEGGPG 

       190        200        210        220        230        240 
GHSLQVLTLF LALTSALLLA LIFITLLFSV LKWIRKKFPH IFKQPFKKTT GAAQEEDACS 

       250 
CRCPQEEEGG GGGYEL

P20334 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools