[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2719656 [NCBI, ExPASy, EBI, Israel, Japan] Powell J.F., Hsu Y.-P.P., Weyler W., Chen S.A., Salach J., Andrikopoulos K., Mallet J., Breakefield X.O.; "The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes."; Biochem. J. 259:407-413(1989).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Thalamus; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
CATALYTIC ACTIVITY: RCH₂NH₂ + H₂O + O₂ = RCHO + NH₃ + H₂O₂.
COFACTOR: FAD.
SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X15609; CAA33632.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X15609; CAA33633.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC122682; AAI22683.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S03974; S03974.

NP_851357.2; -.

3D structure databases

HSSP

P21396; 1O5W. [HSSP ENTRY / PDB]

SMR

P21398; 23-509.

ModBase

P21398.

Family and domain databases

InterPro

IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00757; AMINEOXDASEF.

BLOCKS

P21398.

Genome annotation databases

Ensembl

ENSBTAG00000016206; Bos taurus. [Contig view]

GeneID

281293; -.

KEGG

bta:281293; -.

Phylogenomic databases

HOVERGEN

P21398; -.

Other

ProtoNet

P21398.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine metabolism; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 527`	`527`	`Amine oxidase [flavin-containing] A.`	`PRO_0000099847`
`TOPO_DOM`	`1 497`	`497`	`Cytoplasmic (Potential).`
`TRANSMEM`	`498 518`	`21`	`Anchor for type IV membrane protein (Potential).`
`TOPO_DOM`	`519 527`	`9`	`Mitochondrial intermembrane (Potential).`
`SITE`	`335 335`	`1`	`Important for substrate specificity (By similarity).`
`SITE`	`374 374`	`1`	`Important for catalytic activity (By similarity).`
`MOD_RES`	`406 406`		`S-8alpha-FAD cysteine (By similarity).`
`CONFLICT`	`376 376`		`L -> R (in Ref. 1; CAA33632/CAA33633).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 59758 Da [This is the MW of the unprocessed precursor]

CRC64: BC69ED43644DAF37 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG RTYTVRNEHV 

        70         80         90        100        110        120 
DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY VKGKTYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV EWDKMTMKDL IEKICWTKTA RQFASLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL 

       250        260        270        280        290        300 
RSPVTYVDQS SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 

       310        320        330        340        350        360 
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE QYSGGCYTAY FPPGIMTQYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKLSAKD IWIQEPEAED 

       490        500        510        520 
VPAVEITPSF WERNLPSVSG LLKIVGFSTS ITALWFVMYR FRLLSRS

P21398 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools