[1]	NUCLEOTIDE SEQUENCE. PubMed=2494655 [NCBI, ExPASy, EBI, Israel, Japan] Gould S.J., Subramani S., Scheffler I.E.; "Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species."; Proc. Natl. Acad. Sci. U.S.A. 86:1934-1938(1989).
[2]	ERRATUM. Gould S.J., Subramani S., Scheffler I.E.; Proc. Natl. Acad. Sci. U.S.A. 90:2556-2556(1993).

Comments

CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of two integral membrane proteins (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane.
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

B32394; B32394.

UniGene

Rn.3902

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

SMR

P21913; 1-143.

ModBase

P21913.

Organism-specific databases

RGD

1308598; Sdhb.

Gene expression databases

ArrayExpress

P21913; -.

GermOnline

ENSRNOG00000007967; Rattus norvegicus.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; PARTIAL.
PS51085; 2FE2S_FER_2; PARTIAL.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P21913.

Genome annotation databases

Ensembl

ENSRNOG00000007967; Rattus norvegicus. [Contig view]

Phylogenomic databases

HOVERGEN

P21913; -.

Other

ProtoNet

P21913.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >143`	`>143`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit.`	`PRO_0000158693`
`DOMAIN`	`<1 27`	`>27`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`70 100`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`7 7`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`80 80`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`83 83`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`86 86`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`90 90`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`137 137`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`143 143`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`NON_TER`	`1 1`
`NON_TER`	`143 143`

Sequence information

Length: 143 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 16788 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: CB9D59670007BC3A [This is a checksum on the sequence]

        10         20         30         40         50         60 
GGNTLACTRR IDTNLNKVSK IYPLPHMYVI KDLVPDLSNF YAQYRSIEPY LKKKDESQEG 

        70         80         90        100        110        120 
KQQYLQSIEE REKLDGLYEC ILCACCSTSC PSYWWNGDKY LGPAVLMQAY RWMIDSRDDF 

       130        140 
TEERLAKLQD PFSLYRCHTI MNC

P21913 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools