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UniProtKB/Swiss-Prot entry P22008


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_PSEAE
Primary accession number P22008
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: proC
OrderedLocusNames: PA0393
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-13.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1016/0378-1119(90)90121-7; PubMed=2107123 [NCBI, ExPASy, EBI, Israel, Japan]
Savioz A., Jeenes D.J., Kocher H.P., Haas D.;
"Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.";
Gene 86:107-111(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1016/0378-1119(91)90221-V; PubMed=1676385 [NCBI, ExPASy, EBI, Israel, Japan]
Whitchurch C.B., Hobbs M., Livingston S.P., Krishnapillai V., Mattick J.S.;
"Characterisation of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria.";
Gene 101:33-44(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M33557; AAA25975.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG03782.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M55524; AAA25958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ0418; JQ0418.
RefSeq NP_249084.1; -.
3D structure databases
ModBase P22008.
Enzyme and pathway databases
BioCyc PAER208964:PA0393-MON; -.
Organism-specific databases
PseudoCAP PA0393; -.
Family and domain databases
InterPro IPR002197; HTH_Fis.
IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
PRINTS PR01590; HTHFIS.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS P22008.
Genome annotation databases
GeneID 878413; -.
GenomeReviews AE004091_GR; PA0393.
KEGG pae:PA0393; -.
NMPDR fig|208964.1.peg.394; -.
Phylogenomic databases
HOGENOM P22008; -.
Genome annotation databases
CMR P22008; PA0393.
Other
ProtoNet P22008.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   273  272     Pyrroline-5-carboxylate reductase. PRO_0000187296
Sequence information
Length: 273 AA [This is the length of the unprocessed precursor] Molecular weight: 28094 Da [This is the MW of the unprocessed precursor] CRC64: 6B2D191635E8DEE0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTPRIAFIG AGNMAASLIG GLRAQGVPAA QIRASDPGAE QRAKIAGEFA IDVVESNAEA 

        70         80         90        100        110        120 
VADADVVVLS VKPQAMKAVC QALAPALKPE QLIVSIAAGI PCASLEAWLG QPRPVVRCMP 

       130        140        150        160        170        180 
NTPALLRQGA SGLYANAQVS AAQCEQAGQL LSAVGIALWL DDEAQIDAVT AVSGSGPAYF 

       190        200        210        220        230        240 
FLLMQAMTDA GEKLGLSRET ASRLTLQTAL GAAQMALSSE VEPAELRRRV TSPNGTTEAA 

       250        260        270 
IKSFQANGFE ALVEQALNAA SQRSAELAEQ LGQ 

P22008 in FASTA format

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