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UniProtKB/Swiss-Prot entry P22676


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CALB2_HUMAN
Primary accession number P22676
Secondary accession numbers A8K4Y1 Q53HD2 Q96BK4
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on June 27, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 80)
Name and origin of the protein
Protein name Calretinin
Synonyms CR
29 kDa calbindin
Gene name
Name: CALB2
Synonyms: CAB29
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2618861 [NCBI, ExPASy, EBI, Israel, Japan]
Parmentier M.;
"The human calbindins: cDNA and gene cloning.";
Adv. Exp. Med. Biol. 255:233-240(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1111/j.1432-1033.1991.tb15788.x; PubMed=2001709 [NCBI, ExPASy, EBI, Israel, Japan]
Parmentier M., Lefort A.;
"Structure of the human brain calcium-binding protein calretinin and its expression in bacteria.";
Eur. J. Biochem. 196:79-85(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adipose tissue, and Cerebellum;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X56667; CAA39991.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X56668; CAA39992.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK291096; BAF83785.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222495; BAD96215.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222648; BAD96368.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC015484; AAH15484.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00027264; -.
PIR S14109; A60253.
RefSeq NP_001731.2; -.
NP_009018.1; -.
NP_009019.1; -.
UniGene Hs.106857
3D structure databases
HSSP P02593; 1IWQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase P22676.
PTM databases
PhosphoSite P22676; -.
2D gel databases
REPRODUCTION-2DPAGE IPI00027264; -.
Organism-specific databases
GeneCards GC16P069950; -.
GC16P069951; -.
H-InvDB HIX0013209; -.
HGNC HGNC:1435; CALB2.
GenAtlas CALB2.
HPA CAB000106; -.
HPA007305; -.
HPA007306; -.
MIM 114051; gene. [NCBI / EBI]
PharmGKB PA26027; -.
Gene expression databases
ArrayExpress P22676; -.
Bgee P22676; -.
CleanEx HS_CALB2; -.
GermOnline ENSG00000172137; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011992; EF-Hand_type.
IPR018248; EF_hand.
IPR018247; EF_HAND_1.
IPR018249; EF_HAND_2.
IPR002048; EF_hand_Ca_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.238.10; EF-Hand_type; 1.
Pfam PF00036; efhand; 4.
Pfam graphical view of domain structure.
ProDom PD000012; EF-hand; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00054; EFh; 5.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 5.
PS50222; EF_HAND_2; 5.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P22676; -.
Genome annotation databases
Ensembl ENSG00000172137; Homo sapiens. [Contig view]
GeneID 794; -.
KEGG hsa:794; -.
NMPDR fig|9606.3.peg.12526; -.
Phylogenomic databases
HOGENOM P22676; -.
HOVERGEN P22676; -.
OMA P22676; FQGMKLT.
Other
NextBio 3222; -.
SOURCE CALB2; Homo sapiens.
ProtoNet P22676.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   271  271     Calretinin. PRO_0000073479
DOMAIN   16    51  36     EF-hand 1. 
DOMAIN   63    98  36     EF-hand 2. 
DOMAIN   107   142  36     EF-hand 3. 
DOMAIN   151   186  36     EF-hand 4. 
DOMAIN   195   230  36     EF-hand 5. 
DOMAIN   235   270  36     EF-hand 6. 
CA_BIND   29    40  12     1 (Probable). 
CA_BIND   76    87  12     2; possibly ancestral (Probable). 
CA_BIND   120   131  12     3 (Probable). 
CA_BIND   164   175  12     4 (Probable). 
CA_BIND   208   219  12     5 (Probable). 
CA_BIND   251   262  12     6; possibly ancestral (Probable). 
CONFLICT   110   110        A -> T (in Ref. 5; AAH15484). 
CONFLICT   235   235        M -> I (in Ref. 2; CAA39991). 
Sequence information
Length: 271 AA [This is the length of the unprocessed precursor] Molecular weight: 31540 Da [This is the MW of the unprocessed precursor] CRC64: 98116AD706079DB9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 

        70         80         90        100        110        120 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 

       130        140        150        160        170        180 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 

       190        200        210        220        230        240 
PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL 

       250        260        270 
TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M 

P22676 in FASTA format

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