NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-16.
STRAIN=ATCC 33205 / DSM 43846 / IFO 14230 / JCM 3312 / T-323;
PubMed=1880121 [NCBI, ExPASy, EBI, Israel, Japan]
Takada H., Yoshimura T., Ohshima T., Esaki N., Soda K.;
"Thermostable phenylalanine dehydrogenase of Thermoactinomyces intermedius: cloning, expression, and sequencing of its gene.";
J. Biochem. 109:371-376(1991).

Comments

CATALYTIC ACTIVITY: L-phenylalanine + H₂O + NAD⁺ = phenylpyruvate + NH₃ + NADH.
BIOPHYSICOCHEMICAL PROPERTIES:

Temperature dependence: Thermostable;
PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from phenylpyruvate (PDH route): step 1/1 .
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D00631; BAA00524.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JQ0513; JQ0513.

3D structure databases

HSSP

Q59771; 1C1D. [HSSP ENTRY / PDB]

ModBase

P22823.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016211; Glu/Phe/Leu/Val_DHase_bac/arc.
Graphical view of domain structure.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000188; Phe_leu_dh; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 366`	`366`	`Phenylalanine dehydrogenase.`	`PRO_0000182809`
`NP_BIND`	`181 187`	`7`	`NAD (Potential).`
`ACT_SITE`	`81 81`		`By similarity.`

Sequence information

Length: 366 AA [This is the length of the unprocessed precursor]

Molecular weight: 40488 Da [This is the MW of the unprocessed precursor]

CRC64: 67DFDD87F439D72B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRDVFEMMDR YGHEQVIFCR HPQTGLKAII ALHNTTAGPA LGGCRMIPYA STDEALEDVL 

        70         80         90        100        110        120 
RLSKGMTYKC SLADVDFGGG KMVIIGDPKK DKSPELFRVI GRFVGGLNGR FYTGTDMGTN 

       130        140        150        160        170        180 
PEDFVHAARE SKSFAGLPKS YGGKGDTSIP TALGVFHGMR ATARFLWGTD QLKGRVVAIQ 

       190        200        210        220        230        240 
GVGKVGERLL QLLVEVGAYC KIADIDSVRC EQLKEKYGDK VQLVDVNRIH KESCDIFSPC 

       250        260        270        280        290        300 
AKGGVVNDDT IDEFRCLAIV GSANNQLVED RHGALLQKRS ICYAPDYLVN AGGLIQVADE 

       310        320        330        340        350        360 
LEGFHEERVL AKTEAIYDMV LDIFHRAKNE NITTCEAADR IVMERLKKLT DIRRILLEDP 


RNSARR

P22823 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools