[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Hw; PubMed=1995589 [NCBI, ExPASy, EBI, Israel, Japan] Xi L., Cho K.W., Tu S.C.; "Cloning and nucleotide sequences of lux genes and characterization of luciferase of Xenorhabdus luminescens from a human wound."; J. Bacteriol. 173:1399-1405(1991).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Hw; PubMed=1644764 [NCBI, ExPASy, EBI, Israel, Japan] Meighen E.A., Szittner R.B.; "Multiple repetitive elements and organization of the lux operons of luminescent terrestrial bacteria."; J. Bacteriol. 174:5371-5381(1992).

Comments

FUNCTION: LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
CATALYTIC ACTIVITY: A long-chain aldehyde + CoA + NADP⁺ = a long-chain acyl-CoA + NADPH.
PATHWAY: Lipid metabolism; bioluminescent fatty acid reduction .
SIMILARITY: Belongs to the luxC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M62917; AAA63563.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M90092; AAD05355.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A42951; A42951.

3D structure databases

ModBase

P23113.

Family and domain databases

InterPro

IPR008670; LuxC.
Graphical view of domain structure.

Pfam

PF05893; LuxC; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Luminescence; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 480`	`480`	`Acyl-CoA reductase.`	`PRO_0000220199`
`CONFLICT`	`2 3`		`NK -> PP (in Ref. 1; AAA63563).`
`CONFLICT`	`81 81`		`T -> P (in Ref. 1; AAA63563).`
`CONFLICT`	`86 95`		`LKRYMGYSEE -> PKKIYGIFRR (in Ref. 1; AAA63563).`
`CONFLICT`	`103 103`		`W -> R (in Ref. 1; AAA63563).`
`CONFLICT`	`196 196`		`D -> V (in Ref. 1; AAA63563).`
`CONFLICT`	`209 209`		`Y -> D (in Ref. 1; AAA63563).`

Sequence information

Length: 480 AA [This is the length of the unprocessed precursor]

Molecular weight: 54847 Da [This is the MW of the unprocessed precursor]

CRC64: 57C40EF27BB3810D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNKKISFIIN GRVEIFPESD DLVQSINFGD NSVHLPVLND SQVKNIIDYN ENNELQLHNI 

        70         80         90        100        110        120 
INFLYTVGQR WKNEEYSRRR TYIRDLKRYM GYSEEMAKLE ANWISMILCS KGGLYDLVKN 

       130        140        150        160        170        180 
ELGSRHIMDE WLPQDESYIR AFPKGKSVHL LTGNVPLSGV LSILRAILTK NQCIIKTSST 

       190        200        210        220        230        240 
DPFTANALAL SFIDVDPHHP VTRSLSVVYW QHQGDISLAK EIMQHADVVV AWGGEDAINW 

       250        260        270        280        290        300 
AVKHAPPDID VMKFGPKKSF CIIDNPVDLV SAATGAAHDV CFYDQQACFS TQNIYYMGSH 

       310        320        330        340        350        360 
YEEFKLALIE KLNLYAHILP NTKKDFDEKA AYSLVQKECL FAGLKVEVDV HQRWMVIESN 

       370        380        390        400        410        420 
AGVELNQPLG RCVYLHHVDN IEQILPYVRK NKTQTISVFP WEAALKYRDL LALKGAERIV 

       430        440        450        460        470        480 
EAGMNNIFRV GGAHDGMRPL QRLVTYISHE RPSHYTAKDV AVEIEQTRFL EEDKFLVFVP

P23113 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools