[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 19623 / I-16-M / NCIB 10340 / NCTC 10482; PubMed=2546004 [NCBI, ExPASy, EBI, Israel, Japan] Peoples O.P., Sinskey A.J.; "Fine structural analysis of the Zoogloea ramigera phbA-phbB locus encoding beta-ketothiolase and acetoacetyl-CoA reductase: nucleotide sequence of phbB."; Mol. Microbiol. 3:349-357(1989).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-31. PubMed=3286259 [NCBI, ExPASy, EBI, Israel, Japan] Ploux O., Masamune S., Walsh C.T.; "The NADPH-linked acetoacetyl-CoA reductase from Zoogloea ramigera. Characterization and mechanistic studies of the cloned enzyme over-produced in Escherichia coli."; Eur. J. Biochem. 174:177-182(1988).

Comments

CATALYTIC ACTIVITY: (R)-3-hydroxyacyl-CoA + NADP⁺ = 3-oxoacyl-CoA + NADPH.
PATHWAY: Biopolymer metabolism; poly-(R)-3-hydroxybutyric acid biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	S06998; S06998.
3D structure databases
HSSP	Q12634; 1G0N. [HSSP ENTRY / PDB]
ModBase	P23238.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-13089; -.
Family and domain databases
InterPro	IPR011283; Acetoacetyl-CoA_reductase. IPR002198; DHase_sc/Rdtase_SDR. IPR002347; Glc/ribitol_DHase. IPR016040; NAD(P)-bd. Graphical view of domain structure.
Gene3D	G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER	PTHR19410; ADH_short_C2; 1.
Pfam	PF00106; adh_short; 1. Pfam graphical view of domain structure.
PRINTS	PR00081; GDHRDH. PR00080; SDRFAMILY.
TIGRFAMs	TIGR01829; AcAcCoA_reduct; 1.
PROSITE	PS00061; ADH_SHORT; 1.
BLOCKS	P23238.
Other
ProtoNet	P23238.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NADP; Oxidoreductase; PHB biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 241`	`241`	`Acetoacetyl-CoA reductase.`	`PRO_0000054751`
`NP_BIND`	`7 31`	`25`	`NADP (By similarity).`
`ACT_SITE`	`147 147`		`Proton acceptor (By similarity).`
`BINDING`	`134 134`		`Substrate (By similarity).`

Sequence information

Length: 241 AA [This is the length of the unprocessed precursor]

Molecular weight: 25285 Da [This is the MW of the unprocessed precursor]

CRC64: 8FDD489C0D816804 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSRVALVTGG SRGIGAAISI ALKAAGYKVA ASYAGNDDAA KPFKAETGIA VYKWDVSSYE 

        70         80         90        100        110        120 
ACVEGIAKVE ADLGPIDVLV NNAGITKDAM FHKMTPDQWN AVINTNLTGL FNMTHPVWSG 

       130        140        150        160        170        180 
MRDRSFGRIV NISSINGQKG QMGQANYSAA KAGDLGFTKA LAQEGAAKGI TVNAICPGYI 

       190        200        210        220        230        240 
GTEMVRAIPE KVLNERIIPQ IPVGRLGEPD EIARIVVFLA SDEAGFITGS TISANGGQFF 


V

P23238 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools