[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2017181 [NCBI, ExPASy, EBI, Israel, Japan] Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.; "The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation."; Mol. Cell. Biol. 11:2864-2872(1991).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	PRELIMINARY PROTEIN SEQUENCE OF 2-30. DOI=10.1084/jem.169.4.1497; PubMed=2466944 [NCBI, ExPASy, EBI, Israel, Japan] Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.; "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen."; J. Exp. Med. 169:1497-1502(1989).

Comments

FUNCTION: May be involved in growth regulation in hematopoietic cells.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.
SIMILARITY: Belongs to the tetraspanin (TM4SF) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M57276; AAA41775.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC078900; AAH78900.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A39574; A39574.

NP_036655.1; -.

3D structure databases

ModBase

P24485.

Organism-specific databases

RGD

2310; Cd53.

Gene expression databases

ArrayExpress

P24485; -.

GermOnline

ENSRNOG00000017874; Rattus norvegicus.

Family and domain databases

InterPro

IPR000301; Transmem_4.
Graphical view of domain structure.

Pfam

PF00335; Tetraspannin; 1.
Pfam graphical view of domain structure.

PR00259; TMFOUR.

PS00421; TM4_1; 1.

Genome annotation databases

Ensembl

ENSRNOG00000017874; Rattus norvegicus. [Contig view]

GeneID

24251; -.

KEGG

rno:24251; -.

NMPDR

fig|10116.3.peg.16810; -.

Phylogenomic databases

HOVERGEN

P24485; -.

Other

ProtoNet

P24485.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycoprotein; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 219`	`218`	`Leukocyte surface antigen CD53.`	`PRO_0000219214`
`TOPO_DOM`	`2 11`	`10`	`Cytoplasmic (Potential).`
`TRANSMEM`	`12 32`	`21`	`Potential.`
`TOPO_DOM`	`33 54`	`22`	`Extracellular (Potential).`
`TRANSMEM`	`55 69`	`15`	`Potential.`
`TOPO_DOM`	`70 80`	`11`	`Cytoplasmic (Potential).`
`TRANSMEM`	`81 106`	`26`	`Potential.`
`TOPO_DOM`	`107 181`	`75`	`Extracellular (Potential).`
`TRANSMEM`	`182 206`	`25`	`Potential.`
`TOPO_DOM`	`207 219`	`13`	`Cytoplasmic (Potential).`
`CARBOHYD`	`119 119`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`129 129`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`148 148`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 219 AA [This is the length of the unprocessed precursor]

Molecular weight: 24168 Da [This is the MW of the unprocessed precursor]

CRC64: C73FC368311F172D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL TLGNVLVIVG 

        70         80         90        100        110        120 
SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA ILLFVYEKKI NTLVAEGLND 

       130        140        150        160        170        180 
SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS SDWISGPPSS CPSGADVQGC YKKGQAWFHS 

       190        200        210 
NFLYIGIVTI CVCVIQVLGM SFALTLNCQI DKTSQALGL

P24485 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools