ID   CD53_RAT                Reviewed;         219 AA.
AC   P24485;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-NOV-2008, entry version 60.
DE   RecName: Full=Leukocyte surface antigen CD53;
DE   AltName: Full=Cell surface glycoprotein CD53;
DE   AltName: Full=Leukocyte antigen MRC OX-44;
DE   AltName: CD_antigen=CD53;
GN   Name=Cd53; Synonyms=Ox-44;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=91203909; PubMed=2017181;
RA   Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.;
RT   "The rat leukocyte antigen MRC OX-44 is a member of a new family of
RT   cell surface proteins which appear to be involved in growth
RT   regulation.";
RL   Mol. Cell. Biol. 11:2864-2872(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PRELIMINARY PROTEIN SEQUENCE OF 2-30.
RX   MEDLINE=89176904; PubMed=2466944; DOI=10.1084/jem.169.4.1497;
RA   Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RT   "The primary structure of the human leukocyte antigen CD37, a species
RT   homologue of the rat MRC OX-44 antigen.";
RL   J. Exp. Med. 169:1497-1502(1989).
CC   -!- FUNCTION: May be involved in growth regulation in hematopoietic
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Spleen and thymus, B-cells, monocytes,
CC       macrophages, neutrophils, single (CD4 or CD8) positive thymocytes,
CC       peripheral T-cells.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
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DR   EMBL; M57276; AAA41775.1; -; mRNA.
DR   EMBL; BC078900; AAH78900.1; -; mRNA.
DR   PIR; A39574; A39574.
DR   RefSeq; NP_036655.1; -.
DR   UniGene; Rn.31988; -.
DR   Ensembl; ENSRNOG00000017874; Rattus norvegicus.
DR   GeneID; 24251; -.
DR   KEGG; rno:24251; -.
DR   NMPDR; fig|10116.3.peg.16810; -.
DR   RGD; 2310; Cd53.
DR   HOVERGEN; P24485; -.
DR   NextBio; 602765; -.
DR   ArrayExpress; P24485; -.
DR   GermOnline; ENSRNOG00000017874; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   InterPro; IPR000301; Transmem_4.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Transmembrane.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    219       Leukocyte surface antigen CD53.
FT                                /FTId=PRO_0000219214.
FT   TOPO_DOM      2     11       Cytoplasmic (Potential).
FT   TRANSMEM     12     32       Potential.
FT   TOPO_DOM     33     54       Extracellular (Potential).
FT   TRANSMEM     55     69       Potential.
FT   TOPO_DOM     70     80       Cytoplasmic (Potential).
FT   TRANSMEM     81    106       Potential.
FT   TOPO_DOM    107    181       Extracellular (Potential).
FT   TRANSMEM    182    206       Potential.
FT   TOPO_DOM    207    219       Cytoplasmic (Potential).
FT   CARBOHYD    119    119       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    129    129       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    148    148       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   219 AA;  24168 MW;  C73FC368311F172D CRC64;
     MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL TLGNVLVIVG
     SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA ILLFVYEKKI NTLVAEGLND
     SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS SDWISGPPSS CPSGADVQGC YKKGQAWFHS
     NFLYIGIVTI CVCVIQVLGM SFALTLNCQI DKTSQALGL
//