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UniProtKB/Swiss-Prot entry P24893

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_CAEEL
Primary accession number P24893
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on November 1, 1995 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 66)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: cox-1
Synonyms: coI
ORFNames: MTCE.26
From
Caenorhabditis elegans [TaxID: 6239] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=1551572 [NCBI, ExPASy, EBI, Israel, Japan]
Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.";
Genetics 130:471-498(1992).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-12 AND MET-466.
STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403;
DOI=10.1093/molbev/msg044; PubMed=12644560 [NCBI, ExPASy, EBI, Israel, Japan]
Denver D.R., Morris K., Thomas W.K.;
"Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing.";
Mol. Biol. Evol. 20:393-400(2003).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
DOI=10.1093/nar/18.20.6113; PubMed=2235493 [NCBI, ExPASy, EBI, Israel, Japan]
Okimoto R., Macfarlane J.L., Wolstenholme D.R.;
"Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans.";
Nucleic Acids Res. 18:6113-6118(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X54252; CAA38159.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171193; AAO16252.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171194; AAO16256.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171195; AAO16260.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171196; AAO16264.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171197; AAO16268.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171198; AAO16272.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171199; AAO16276.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171200; AAO16280.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171201; AAO16284.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171202; AAO16288.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171203; AAO16292.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171204; AAO16296.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171205; AAO16300.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171206; AAO16304.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY171207; AAO16308.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S26034; S26034.
RefSeq NP_006961.1; -.
3D structure databases
HSSP P98002; 1AR1. [HSSP ENTRY / PDB]
ModBase P24893.
Organism-specific databases
WormPep MTCE.26; CE34071. [WormPep / WorfDB]
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (non-traceable author statement from UniProtKB).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0006123; Biological process: mitochondrial electron transport, cytochrome c to oxygen (non-traceable author statement from UniProtKB).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P24893.
Genome annotation databases
Ensembl MTCE.26; Caenorhabditis elegans. [Contig view]
GeneID 2565700; -.
KEGG cel:COX1; -.
Other
NextBio 953875; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Polymorphism; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   525  525     Cytochrome c oxidase subunit 1. PRO_0000183298
TRANSMEM   25    45  21     Potential. 
TRANSMEM   71    91  21     Potential. 
TRANSMEM   108   128  21     Potential. 
TRANSMEM   152   172  21     Potential. 
TRANSMEM   190   210  21     Potential. 
TRANSMEM   241   261  21     Potential. 
TRANSMEM   274   294  21     Potential. 
TRANSMEM   317   337  21     Potential. 
TRANSMEM   344   364  21     Potential. 
TRANSMEM   387   407  21     Potential. 
TRANSMEM   420   440  21     Potential. 
TRANSMEM   459   479  21     Potential. 
METAL   69    69        Iron (heme A axial ligand) (Probable). 
METAL   247   247        Copper B (Probable). 
METAL   251   251        Copper B (Probable). 
METAL   297   297        Copper B (Probable). 
METAL   298   298        Copper B (Probable). 
METAL   383   383        Iron (heme A3 axial ligand) (Probable). 
METAL   385   385        Iron (heme A axial ligand) (Probable). 
CROSSLNK   247   251        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
VARIANT   12    12  1     A -> S (in strain: CB4856 and CB4857). 
VARIANT   466   466  1     I -> M (in strain: AB1, AB2, CB4852, CB4853, CB4855, CB4857, CB4858, KR314 and PB306). 
Sequence information
Length: 525 AA [This is the length of the unprocessed precursor] Molecular weight: 58464 Da [This is the MW of the unprocessed precursor] CRC64: E3D051208B09396F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNLYKKYQGG LAVWLESSNH KDIGTLYFIF GLWSGMVGTS FSLLIRLELA KPGFFLSNGQ 

        70         80         90        100        110        120 
LYNSVITAHA ILMIFFMVMP TMIGGFGNWL LPLMLGAPDM SFPRLNNLSF WLLPTSMLLI 

       130        140        150        160        170        180 
LDACFVDMGC GTSWTVYPPL STMGHPGSSV DLAIFSLHAA GLSSILGGIN FMCTTKNLRS 

       190        200        210        220        230        240 
SSISLEHMTL FVWTVFVTVF LLVLSLPVLA GAITMLLTDR NLNTSFFDPS TGGNPLIYQH 

       250        260        270        280        290        300 
LFWFFGHPEV YILILPAFGI VSQSTLYLTG KKEVFGALGM VYAILSIGLI GCVVWAHHMY 

       310        320        330        340        350        360 
TVGMDLDSRA YFSAATMVIA VPTGVKVFSW LATLFGMKMV FNPLLLWVLG FIFLFTLGGL 

       370        380        390        400        410        420 
TGVVLSNSSL DIILHDTYYV VSHFHYVLSL GAVFGIFTGV TLWWSFITGY VLDKLMMSAV 

       430        440        450        460        470        480 
FILLFIGVNL TFFPLHFAGL HGFPRKYLDY PDVYSVWNII ASYGSIISTA GLFLFIYVLL 

       490        500        510        520 
ESFFSYRLVI SDYYSNSSPE YCMSNYVFGH SYQSEIYFST TSLKN
P24893 in FASTA format

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