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UniProtKB/Swiss-Prot entry P24984

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_COTJA
Primary accession number P24984
Secondary accession number Q8SEX1
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on September 26, 2003 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: MT-CO1
Synonyms: COI, COXI, MTCO1
From
Coturnix coturnix japonica (Japanese quail) [TaxID: 93934] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Perdicinae; Coturnix.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Blood;
DOI=10.1046/j.1365-2052.2001.00795.x; PubMed=11736810 [NCBI, ExPASy, EBI, Israel, Japan]
Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.;
"Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species.";
Anim. Genet. 32:380-385(2001).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
TISSUE=Liver;
DOI=10.1007/BF02515387; PubMed=1706782 [NCBI, ExPASy, EBI, Israel, Japan]
Desjardins P., Morais R.;
"Nucleotide sequence and evolution of coding and noncoding regions of a quail mitochondrial genome.";
J. Mol. Evol. 32:153-161(1991).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 463-516.
TISSUE=Liver;
Ramirez V., Morais R.;
"Nucleotide sequence of mitochondrial genes for COI, tRNAs Lys, Asp, Ser (UCN), COII and ATPases 8 and 6 of the quail Coturnix japonica.";
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP003195; BAB62917.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X57246; CAA40524.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36794; AAA76729.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S25424; S25424.
RefSeq NP_572016.1; -.
3D structure databases
SMR P24984; 3-515.
ModBase P24984.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P24984.
Genome annotation databases
GeneID 804670; -.
Phylogenomic databases
HOVERGEN P24984; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   516  516     Cytochrome c oxidase subunit 1. PRO_0000183316
TRANSMEM   18    38  21     Potential. 
TRANSMEM   57    77  21     Potential. 
TRANSMEM   103   123  21     Potential. 
TRANSMEM   146   166  21     Potential. 
TRANSMEM   184   204  21     Potential. 
TRANSMEM   235   255  21     Potential. 
TRANSMEM   269   289  21     Potential. 
TRANSMEM   311   331  21     Potential. 
TRANSMEM   339   359  21     Potential. 
TRANSMEM   381   401  21     Potential. 
TRANSMEM   415   435  21     Potential. 
TRANSMEM   457   477  21     Potential. 
METAL   62    62        Iron (heme A axial ligand) (Probable). 
METAL   241   241        Copper B (Probable). 
METAL   245   245        Copper B (Probable). 
METAL   291   291        Copper B (Probable). 
METAL   292   292        Copper B (Probable). 
METAL   377   377        Iron (heme A3 axial ligand) (Probable). 
METAL   379   379        Iron (heme A axial ligand) (Probable). 
CROSSLNK   241   245        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
CONFLICT   474   474        W -> L (in Ref. 3; AAA76729). 
Sequence information
Length: 516 AA [This is the length of the unprocessed precursor] Molecular weight: 56985 Da [This is the MW of the unprocessed precursor] CRC64: 34779829B535B2B6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTFINRWLFS TNHKDIGTLY LIFGTWAGMA GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 

        70         80         90        100        110        120 
AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTVE 

       130        140        150        160        170        180 
AGAGTGWTVY PPLAGNLAHA GASVDLAIFS LHLAGVSSIL GAINFITTII NMKPPALSQY 

       190        200        210        220        230        240 
QTPLFVWSVL ITAILLLLSL PVLAAGITML LTDRNLNTTF FDPAGGGDPI LYQHLFWFFG 

       250        260        270        280        290        300 
HPEVYILILP GFGIISHVVA YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV 

       310        320        330        340        350        360 
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDPPML WALGFIFLFT IGGLTGIVLA 

       370        380        390        400        410        420 
NSSLDIALHD TYYVVAHFHY VLSMGAVFAI LAGFTHWFPL FTGFTLHPTW TKAHFGVMFT 

       430        440        450        460        470        480 
GVNLTFFPQH FLGLAGMPRR YSDYPDAYTL WNTLSSIGSL ISMTAVIMLM FIVWEAFSAK 

       490        500        510 
RKVLQPELTA TNIEWIHGCP PPYHTFEEPA FVQVQE
P24984 in FASTA format

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