ID   TR2M2_AGRVI             Reviewed;         755 AA.
AC   P25017;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Tryptophan 2-monooxygenase;
DE            EC=1.13.12.3;
GN   Name=iaaM;
OS   Agrobacterium vitis (Rhizobium vitis).
OG   Plasmid pTiTM4.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TM4;
RX   MEDLINE=91329707; PubMed=1868204; DOI=10.1007/BF00023438;
RA   Bonnard G., Vincent F., Otten L.;
RT   "Sequence of Agrobacterium tumefaciens biotype III auxin genes.";
RL   Plant Mol. Biol. 16:733-738(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CG474;
RA   Otten L., de Ruffray P.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-tryptophan + O(2) = (indol-3-yl)acetamide +
CC       CO(2) + H(2)O.
CC   -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC   -!- SIMILARITY: Belongs to the tryptophan 2-monooxygenase family.
CC   -!- CAUTION: The plasmid pTiTM4 carries two T-regions, the TA and TB
CC       region, both of which have a functional iaaM gene, with low
CC       homology between them.
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DR   EMBL; X56185; CAA39646.1; -; Genomic_DNA.
DR   EMBL; U83987; AAB41874.1; -; Genomic_DNA.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050361; F:tryptophan 2-monooxygenase activity; IEA:InterPro.
DR   GO; GO:0009851; P:auxin biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000759; Adrndx_reductase.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR006064; Glycosidase.
DR   InterPro; IPR012142; Trp_2-mOase.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF02027; RolB_RolC; 1.
DR   PIRSF; PIRSF000319; Trp_2-mono_O2ase; 1.
DR   PRINTS; PR00419; ADXRDTASE.
PE   3: Inferred from homology;
KW   Auxin biosynthesis; Crown gall tumor; Monooxygenase; Oxidoreductase;
KW   Plasmid.
FT   CHAIN         1    755       Tryptophan 2-monooxygenase.
FT                                /FTId=PRO_0000065591.
SQ   SEQUENCE   755 AA;  83973 MW;  6FA63E502343136F CRC64;
     MSASSLLDKQ CDHFSTKIVD LIMVDKADEL DRRVAAAFSE REASRERRIS QISGECNAGL
     ACKRLADGRF PEISAGQRVA VLSAYIYVGE EILRWILEPE ASVRTRVSGL VAIDLAPSCM
     DISRAQLLQT MNLLSGKRCA PSDLSHFVAI SISETARSRT LQMAPYEEGS LKSVTGFTVI
     IEEAVPFDMV AYGRNLMLKA SAGSFPTIDL LYDYRLFLDK CSDSGRIGFF PEDVPRPKVA
     VIGAGISGLV VASELLHAGV DDVTIYEAGD RVGGKLWSHA FKDAPGVVAE MGAMRFPPAA
     SCLFFFLERY GLSSMRPFPN PGTVDTDLVY EGCRYMWKAG QQPPKLFHRV YSGWHAFLKD
     GFLEGDIVLA SPDAITEALK SGDIRRAHDS WQIWLNRFGR ESFSSAIERI FLGTHPPGGE
     TWSFPHDWDL FKLMGIGSGG FGPVFESGFT EILRLVINGY EENQRMCSEG ISELPRRIAS
     QVVNGVSVSQ RIRHVQVRAI EKEKTKIKIR LKSGISELYD KVVVTSGLAN IQLRHCLTCD
     TTIFRAPVNQ AVDNSHMTGS SKLFLLTERK FWFDHMLPSC VLMDGFAKAV YCLDYEPQDP
     NGKGLVLISY TWEDDSHKLL AVPDKKERLC LLRDAISKSF PVFAQHLVPA CADYDQNVVQ
     HDWLTDENAG GRFKLNRRGE DFYSEELFFQ ALDTTNDTGV YLAGCSCSFT GGWVEGAIQT
     ACNAVCAIIH NCGGILAKDN PLKHPWKRYN YRNRN
//