NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sp6;
DOI=10.1007/BF00334360; PubMed=2664449 [NCBI, ExPASy, EBI, Israel, Japan]
Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M.;
"Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
Mol. Gen. Genet. 216:224-229(1989).

Comments

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H₂O = 1-(5-phosphoribosyl)-AMP + diphosphate.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PRA-PH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X61207; CAA43520.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S16803; S16803.

3D structure databases

ModBase

P26722.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004636;	Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105;	Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01020; -; 1.
PBIL [Tree]

InterPro

IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.

Pfam

PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.

ProDom

PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03188; histidine_hisI; 1.

ProtoNet

P26722.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 111`	`111`		`Phosphoribosyl-ATP pyrophosphatase.`	`PRO_0000136341`

Sequence information

Length: 111 AA [This is the length of the unprocessed precursor]

Molecular weight: 11946 Da [This is the MW of the unprocessed precursor]

CRC64: EA8BDE3A36864500 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAEDKISAAV LDRLYATVQA RKGADPETSY TAKLFHRGTA KIAQKVGEEA VETVIEAVRG 

        70         80         90        100        110 
DKAAMASESA DLLYHLMVLW ADAGLEPAAV WEKLAQREGT SGIAEKNARK S

P26722 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools