NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2013566 [NCBI, ExPASy, EBI, Israel, Japan]
van der Meer J.R., Eggen R.I., Zehnder A.J., de Vos W.M.;
"Sequence analysis of the Pseudomonas sp. strain P51 tcb gene cluster, which encodes metabolism of chlorinated catechols: evidence for specialization of catechol 1,2-dioxygenases for chlorinated substrates.";
J. Bacteriol. 173:2425-2434(1991).

Comments

CATALYTIC ACTIVITY: 3-oxoadipate + NAD(P)⁺ = 2-maleylacetate + NAD(P)H.
PATHWAY: Aromatic compound metabolism; 3-chlorocatechol degradation .
SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase family.
CAUTION: Was originally (PubMed:2013566) thought to be a trans-dienelactoneisomerase.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M57629; AAD13629.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E43673; E43673.

3D structure databases

ModBase

P27101.

Ontologies

GO:0018506;	Molecular function: maleylacetate reductase activity (non-traceable author statement from UniProtKB).
GO:0046872;	Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0046300;	Biological process: 2,4-dichlorophenoxyacetic acid catabolic process (non-traceable author statement from UniProtKB).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001670; Fe_AlcDHase.
Graphical view of domain structure.

Pfam

PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.

PROSITE

PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; FALSE_NEG.

ProtoNet

P27101.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 352`	`352`		`Maleylacetate reductase.`	`PRO_0000087849`

Sequence information

Length: 352 AA [This is the length of the unprocessed precursor]

Molecular weight: 37499 Da [This is the MW of the unprocessed precursor]

CRC64: C72A9D2671FFFAB3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNFIHDPLTP RVLFGAGRLQ SLGEELKLLG IRRVLVISTP EQRELANQVA ALIPGSVAGF 

        70         80         90        100        110        120 
FDRATMHVPS QIVDQAASVA RELGVDSYVA PGGGSTIGLA KMLALHSSLP IVAIPTTYAG 

       130        140        150        160        170        180 
SEMTSIYGVT ENELKKTGRD RRVLARTVIY DPELTFGLPT GISVTSGLNA IAHAVEGLYA 

       190        200        210        220        230        240 
PEVNPILAIM AQQGIAALAK SIPTIRSAPT DLEARSQAQY GAWLCGSVLG NVSMALHHKL 

       250        260        270        280        290        300 
CHTLGGTFNL PHAETHTVVL PHALAYNTPA IPRANAWLQE ALATREPAQA LFDLAKSNGA 

       310        320        330        340        350 
PVSLQSIGMK EADLDRACEL VMSAQYPNPR PLEKHAIANL LRRAYLGEPP QP

P27101 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools