ID   AL1A1_CHICK             Reviewed;         509 AA.
AC   P27463;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   04-NOV-2008, entry version 62.
DE   RecName: Full=Retinal dehydrogenase 1;
DE            Short=RALDH 1;
DE            Short=RalDH1;
DE            EC=1.2.1.36;
DE   AltName: Full=Aldehyde dehydrogenase family 1 member A1;
DE   AltName: Full=Aldehyde dehydrogenase, cytosolic;
DE   AltName: Full=ALHDII;
DE   AltName: Full=ALDH-E1;
GN   Name=ALDH1A1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic retina;
RX   MEDLINE=92217647; PubMed=1559558; DOI=10.1016/S0014-4835(05)80219-2;
RA   Godbout R.;
RT   "High levels of aldehyde dehydrogenase transcripts in the
RT   undifferentiated chick retina.";
RL   Exp. Eye Res. 54:297-305(1992).
CC   -!- FUNCTION: Binds free retinal and cellular retinol-binding protein-
CC       bound retinal. Can convert/oxidize retinaldehyde to retinoic acid
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Retinal + NAD(+) + H(2)O = retinoate + NADH.
CC   -!- PATHWAY: Cofactor metabolism; retinol metabolism.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; X58869; CAA41679.1; -; mRNA.
DR   PIR; S14629; S14629.
DR   RefSeq; NP_989908.1; -.
DR   UniGene; Gga.4119; -.
DR   HSSP; P51977; 1BXS.
DR   Ensembl; ENSGALG00000015147; Gallus gallus.
DR   GeneID; 395264; -.
DR   KEGG; gga:395264; -.
DR   HOVERGEN; P27463; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0001758; F:retinal dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN         1    509       Retinal dehydrogenase 1.
FT                                /FTId=PRO_0000056421.
FT   NP_BIND     254    259       NAD (By similarity).
FT   ACT_SITE    277    277       Proton acceptor (By similarity).
FT   ACT_SITE    311    311       Nucleophile (By similarity).
FT   SITE        178    178       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   509 AA;  55809 MW;  7771181FA2F05DA9 CRC64;
     MKKQGSPSNP APVLPALPEP LKDLKIKYTK IFINNEWHDS VSGKKFEVFN PANEEKICEV
     AEGDKADIDK AVKAARKAFE LGSPWRTMDA SERGRLLNKL ADLVERDRLT LATMEAIDGG
     KLFSTAYLMD LGACIKTIRY CAGWADKIHG RTVPMDGNFF TFTRHEPVGV CGQIIPWNFP
     LVMFIWKIAP ALCCGNTVVV KPAEQTPLSA LYMGSLIKEA GFPPGVVNIV PGFGPTAGAA
     ISHHMDIDKV SFTGSTEVGK LIKEAAGKTN LKRVTLELGG KSPNIIFADA DLDEAAEFAH
     IGLFYHQGQC CIAGSRIFVE EPIYDEFVRR SIERAKKYTL GDPLLPGVQQ GPQIDKEQFQ
     KILDLIESGK KEGAKLECGG GPWGNKGYFI QPTVFSNVTD DMRIAKEEIF GPVQQIMKFK
     TIDEVIKRAN NTTYGLAAAV FTKDIDKALT FASALQAGTV WVNCYSAFSA QCPFGGFKMS
     GNGRELGEYG LQEYTEVKTV TIKIPQKNS
//