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UniProtKB/Swiss-Prot entry P27771


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_TREPA
Primary accession number P27771
Secondary accession number O83775
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on December 15, 1998 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: proC
OrderedLocusNames: TP_0797
From
Treponema pallidum [TaxID: 160] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Nichols;
PubMed=2188947 [NCBI, ExPASy, EBI, Israel, Japan]
Gherardini F.C., Hobbs M.M., Stamm L.V., Bassford P.J. Jr.;
"Complementation of an Escherichia coli proC mutation by a gene cloned from Treponema pallidum.";
J. Bacteriol. 172:2996-3002(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
DOI=10.1126/science.281.5375.375; PubMed=9665876 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
Science 281:375-388(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M73825; AAA27478.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000520; AAC65760.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D71281; D71281.
RefSeq NP_219234.1; -.
3D structure databases
ModBase P27771.
Enzyme and pathway databases
BioCyc TPAL243276:TP_0797-MON; -.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS P27771.
Genome annotation databases
GeneID 2610812; -.
GenomeReviews AE000520_GR; TP_0797.
KEGG tpa:TP0797; -.
NMPDR fig|243276.1.peg.793; -.
TIGR TP_0797; -.
Phylogenomic databases
HOGENOM P27771; -.
Other
ProtoNet P27771.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   263  263     Pyrroline-5-carboxylate reductase. PRO_0000187310
CONFLICT   1    65        MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKL RAQCTSLGIGACASVQELVQKSEWI -> MTWDFWVLEQWDGRWQKGWCTQERCKRSSVRLCVKSGKVA CAVYIFGHRCLRVSSGTGTEKVNGF (in Ref. 1). 
CONFLICT   77    93        VLRDRQSFQGKVLISLA -> GTARSPIFQESAISC (in Ref. 1; AAA27478). 
CONFLICT   256   260        VRAAL -> CRWLS (in Ref. 1). 
Sequence information
Length: 263 AA [This is the length of the unprocessed precursor] Molecular weight: 27645 Da [This is the MW of the unprocessed precursor] CRC64: ED4AD7C54BAF9D61 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNVGFLGFGA MGRALAEGLV HAGALQAAQV YACALNQEKL RAQCTSLGIG ACASVQELVQ 

        70         80         90        100        110        120 
KSEWIFLAVK PSQISTVLRD RQSFQGKVLI SLAAGMSCAA YEALFAADPH QGIRHLSLLP 

       130        140        150        160        170        180 
NLPCQVARGV IIAEARHTLH HDEHAALLAV LRTVAQVEVV DTAYFAIAGV IAGCAPAFAA 

       190        200        210        220        230        240 
QFIEALADAG VRYGLARDQA YRLAAHMLEG TAALIQHSGV HPAQLKDRVC SPAGSTIRGV 

       250        260 
LALEEQGLRR AVIHAVRAAL SSS 

P27771 in FASTA format

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