ID   QOR_ECOLI               Reviewed;         327 AA.
AC   P28304; Q2M6Q3;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-NOV-2008, entry version 76.
DE   RecName: Full=Quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
DE   AltName: Full=Zeta-crystallin homolog protein;
GN   Name=qor; Synonyms=hcz; OrderedLocusNames=b4051, JW4011;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Dixon N.E., Lilley P.E.;
RL   Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=94089392; PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA   Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J.,
RA   Daniels D.L.;
RT   "Analysis of the Escherichia coli genome. IV. DNA sequence of the
RT   region from 89.2 to 92.8 minutes.";
RL   Nucleic Acids Res. 21:5408-5417(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RX   MEDLINE=95326140; PubMed=7602590; DOI=10.1006/jmbi.1995.0337;
RA   Thorn J.M., Barton J.D., Dixon N.E., Ollis D.L., Edwards K.J.;
RT   "Crystal structure of Escherichia coli QOR quinone oxidoreductase
RT   complexed with NADPH.";
RL   J. Mol. Biol. 249:785-799(1995).
CC   -!- CATALYTIC ACTIVITY: NADPH + 2 quinone = NADP(+) + 2 semiquinone.
CC   -!- SUBUNIT: Homodimer.
CC   -!- INTERACTION:
CC       P0A6Y8:dnaK; NbExp=1; IntAct=EBI-556687, EBI-542092;
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
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DR   EMBL; L02312; AAA23691.1; -; Genomic_DNA.
DR   EMBL; U00006; AAC43145.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77021.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78053.1; -; Genomic_DNA.
DR   PIR; S45529; S45529.
DR   RefSeq; AP_004552.1; -.
DR   RefSeq; NP_418475.1; -.
DR   PDB; 1QOR; X-ray; 2.20 A; A/B=1-327.
DR   PDB; 2FRO; Model; -; A=3-327.
DR   PDBsum; 1QOR; -.
DR   PDBsum; 2FRO; -.
DR   DIP; DIP:10631N; -.
DR   IntAct; P28304; -.
DR   GeneID; 948556; -.
DR   GenomeReviews; U00096_GR; b4051.
DR   GenomeReviews; AP009048_GR; JW4011.
DR   KEGG; ecj:JW4011; -.
DR   KEGG; eco:b4051; -.
DR   EchoBASE; EB1455; -.
DR   EcoGene; EG11492; qor.
DR   HOGENOM; P28304; -.
DR   BioCyc; EcoCyc:QOR-MON; -.
DR   BioCyc; MetaCyc:QOR-MON; -.
DR   LinkHub; P28304; -.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR013154; AlcDHase_GroES-like.
DR   InterPro; IPR002085; AlcDHase_SF_Zn.
DR   InterPro; IPR013149; AlcDHase_Zn-bd.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    327       Quinone oxidoreductase.
FT                                /FTId=PRO_0000160901.
FT   STRAND        3      9
FT   HELIX        13     15
FT   STRAND       17     20
FT   STRAND       30     39
FT   HELIX        42     48
FT   STRAND       55     59
FT   STRAND       65     72
FT   STRAND       84     88
FT   STRAND       95    102
FT   HELIX       103    105
FT   STRAND      106    108
FT   HELIX       115    133
FT   STRAND      143    148
FT   HELIX       152    164
FT   STRAND      167    174
FT   HELIX       175    184
FT   STRAND      187    191
FT   TURN        192    194
FT   HELIX       197    204
FT   TURN        205    207
FT   STRAND      210    215
FT   HELIX       219    221
FT   HELIX       222    227
FT   STRAND      229    237
FT   HELIX       251    255
FT   STRAND      260    262
FT   HELIX       266    269
FT   HELIX       273    288
FT   HELIX       298    300
FT   STRAND      301    303
FT   HELIX       304    306
FT   HELIX       307    315
FT   STRAND      324    326
SQ   SEQUENCE   327 AA;  35172 MW;  A6355B12DBA513B2 CRC64;
     MATRIEFHKH GGPEVLQAVE FTPADPAENE IQVENKAIGI NFIDTYIRSG LYPPPSLPSG
     LGTEAAGIVS KVGSGVKHIK AGDRVVYAQS ALGAYSSVHN IIADKAAILP AAISFEQAAA
     SFLKGLTVYY LLRKTYEIKP DEQFLFHAAA GGVGLIACQW AKALGAKLIG TVGTAQKAQS
     ALKAGAWQVI NYREEDLVER LKEITGGKKV RVVYDSVGRD TWERSLDCLQ RRGLMVSFGN
     SSGAVTGVNL GILNQKGSLY VTRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAEQQ
     KYPLKDAQRA HEILESRATQ GSSLLIP
//